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http://hdl.handle.net/2445/185201
Title: | Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy |
Author: | Mao, Xiaoman Calero Pérez, Pilar Montpeyó, David Bruna, Jordi Yuste, Victor J. Candiota, Ana Paula Lorenzo, Julia Novio, Fernando Ruiz Molina, Daniel |
Keywords: | Glioma Nanopartícules Gliomas Nanoparticles |
Issue Date: | 5-Apr-2022 |
Publisher: | MDPI |
Abstract: | Cisplatin has been described as a potent anticancer agent for decades. However, in the case of glioblastomas, it is only considered a rescue treatment applied after the failure of second-line treatments. Herein, based on the versatility offered by coordination chemistry, we engineered nanoparticles by reaction of a platinum (IV) prodrug and iron metal ions showing in vitro dual pH- and redox-sensitivity, controlled release and comparable cytotoxicity to cisplatin against HeLa and GL261 cells. In vivo intranasal administration in orthotopic preclinical GL261 glioblastoma tumor-bearing mice demonstrated increased accumulation of platinum in tumors, leading in some cases to complete cure and prolonged survival of the tested cohort. This was corroborated by a magnetic resonance imaging follow-up, thus opening new opportunities for intranasal glioblastoma therapies while minimizing side effects. The findings derived from this research showed the potentiality of this approach as a novel therapy for glioblastoma treatment. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/nano12071221 |
It is part of: | Nanomaterials, 2022, vol. 12, num. 7 |
URI: | http://hdl.handle.net/2445/185201 |
Related resource: | https://doi.org/10.3390/nano12071221 |
ISSN: | 2079-4991 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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nanomaterials-12-01221-v2.pdf | 3.5 MB | Adobe PDF | View/Open |
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