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Title: | Secretory immunoglobulin A (s-IgA) reactivity to acute psychosocial stress in children and adolescents: The influence of pubertal development and history of maltreatment. |
Author: | Marques-Feixa, Laia Castro Quintas, Águeda Palma-Gudiel, Helena Romero, Soledad Morer, Astrid Rapado-Castro, Marta Martín, María Zorrilla, Iñaki Blasco-Fontecilla, Hilario Ramírez, Maite Mayoral, María Mendez, Iría San Martín-Gonzalez, Nerea Rodrigo-Yanguas María Monteserín-García, José Luis Fañanás Saura, Lourdes EPI-Young Stress GROUP |
Keywords: | Infants Adolescents Maltractament infantil Tests psicològics Immunoglobulina A Children Teenagers Child abuse Psychological tests Immunoglobulin A |
Issue Date: | 12-Apr-2022 |
Publisher: | Elsevier |
Abstract: | Background: Mucosal secretory immunoglobulin A (s-IgA) is an antibody protein-complex that plays a crucial role in immune first defense against infection. Although different immune biomarkers have been associated with stress-related psychopathology, s-IgA remains poorly studied, especially in youth. Objectives: The present study investigated how s-IgA behaves in front of acute psychosocial stress in children and adolescents, including possible variability associated with developmental stage and history of childhood maltreatment (CM). Methods: 94 children and adolescents from 7 to 17 years (54 with a current psychiatric diagnostic and 40 healthy controls) drawn from a larger Spanish study were explored (EPI-Young Stress Project). To assess biological reactivity, participants provided five saliva samples during an acute laboratory-based psychosocial stressor, the Trier Social Stress Test for Children (TSST-C). Samples were assayed for s-IgA, as well as for cortisol. Pubertal development was ascertained by Tanner stage and CM following TASSCV criteria. Results: We observed s-IgA fluctuations throughout the stressor, indicating the validity of TSST-C to stimulate s-IgA secretion (F(4,199) = 6.200, p <.001). Although s-IgA trajectories followed a reactivity and recovery pattern in adolescents, children exhibited no s-IgA response when faced with stress (F(4,197) = 3.406, p =.010). An interaction was found between s-IgA and CM (F(4,203) = 2.643, p =.035). Interestingly, an interaction between developmental stage, CM history and s-IgA reactivity was identified (F(12,343) = 2.036, p =.017); while children non-exposed to maltreatment exhibited no s-IgA changes to acute stress, children with a history of CM showed a similar response to adolescents, increasing their s-IgA levels after the psychosocial stressor. Conclusion: Acute psychosocial stress stimulates s-IgA secretion, but only after puberty. However, children with a history of maltreatment exhibited a response resembling that of adolescents, suggesting an early maturation of the immune system. Further studies are needed to clarify the validity of s-IgA as an acute stress biomarker, including additional measures during stress exposure. Keywords: Acute stress; Adolescents; Childhood maltreatment; Children; Developmental stage; TSST-C; secretory Immunoglobulin A (s-IgA). |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.bbi.2022.04.010 |
It is part of: | Brain, Behavior, and Immunity, 2022, vol. 103, p. 122-129 |
URI: | http://hdl.handle.net/2445/185209 |
Related resource: | https://doi.org/10.1016/j.bbi.2022.04.010 |
ISSN: | 0889-1591 |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) |
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