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http://hdl.handle.net/2445/185217
Title: | Duration of untreated illness and bipolar disorder: time for a new definition? Results from a cross-sectional study |
Author: | Fico, Giovanna Anmella, Gerard Gómez Ramiro, Marta Miquel, Carlota de Hidalgo Mazzei, Diego Manchia, Mirko Alda, Martin González-Pinto, Ana Carvalho, André F. Vieta i Pascual, Eduard, 1963- Murru, Andrea |
Keywords: | Trastorn bipolar Cognició Psicodiagnòstic Trastorns afectius Manic-depressive illness Cognition Psychodiagnostics Affective disorders |
Issue Date: | 1-Nov-2021 |
Publisher: | Elsevier B.V. |
Abstract: | Background: We primarily aimed to explore the associations between duration of untreated illness (DUI), treatment response, and functioning in a cohort of patients with bipolar disorder (BD). Methods: 261 participants with BD were recruited. DUI was defined as months from the first affective episode to the start of a mood-stabilizer. The functioning assessment short test (FAST) scores and treatment response scores for lithium, valproate, or lamotrigine according to the Alda Scale Total Score (TS) were compared between patients with short (<24 months) or long DUI. Differences in FAST scores among good (GR; TS≥7), poor (PR; TS=2-6), or non-responders (NR; TS<2) to each mood-stabilizer were analyzed. Linear regression was computed using the FAST global score as the dependent variable. Results: DUI and FAST scores showed no statistically significant correlation. Patients with a longer DUI showed poorer response to lithium (Z=-3.196; p<0.001), but not to valproate or lamotrigine. Response to lithium (β=-1.814; p<0.001), number of hospitalizations (β=0.237; p<0.001), and illness duration (β=0.160; p=0.028) were associated with FAST total scores. GR to lithium was associated with better global functioning compared to PR or NR [H=27.631; p<0.001]. Limitations: The retrospective design could expose our data to a recall bias. Also, only few patients were on valproate or lamotrigine treatment. Conclusions: Poor functioning in BD could be the result of multiple affective relapses, rather than a direct effect of DUI. A timely diagnosis with subsequent effective prophylactic treatment, such as lithium, may prevent poor functional outcomes in real-world patients with BD. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.jad.2021.07.062 |
It is part of: | Journal of Affective Disorders, 2021, vol. 294, p. 513-520 |
URI: | http://hdl.handle.net/2445/185217 |
Related resource: | https://doi.org/10.1016/j.jad.2021.07.062 |
ISSN: | 0165-0327 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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