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Title: Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
Author: Sánchez Benavides, Gonzalo
Salvadó, Gemma
Arenaza Urquijo, Eider M.
Grau Rivera, Oriol
Suárez Calvet, Marc
Milà Alomà, Marta
González de Echávarri, José M.
Minguillon, Carolina
Crous Bou, Marta
Niñerola Baizán, Aida
Perissinotti, Andrés
Gispert, Juan Domingo
Molinuevo, José Luis
ALFA Study
Keywords: Malaltia d'Alzheimer
Trastorns de la cognició
Alzheimer's disease
Cognition disorders
Issue Date: 11-Nov-2020
Publisher: Alzheimer's Association
Abstract: Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals. Methods: A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status. Results: Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003). Discussion: Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.
Note: Reproducció del document publicat a:
It is part of: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) , 2020, vol. 12, num. 1
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ISSN: 2352-8729
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Biomedicina)

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