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Title: | Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila |
Author: | Rech, Gabriel E. Radío, Santiago Guirao Rico, Sara Aguilera, Laura Horvath, Vivien Green, Llewellyn Lindstadt, Hannah Jamilloux, Véronique Quesneville, Hadi González, Josefa |
Keywords: | Drosòfila Expressió gènica Drosophila Gene expression |
Issue Date: | 12-Apr-2022 |
Publisher: | Nature Publishing Group |
Abstract: | High quality reference genomes are crucial to understanding genome function, structure and evolution. The availability of reference genomes has allowed us to start inferring the role of genetic variation in biology, disease, and biodiversity conservation. However, analyses across organisms demonstrate that a single reference genome is not enough to capture the global genetic diversity present in populations. In this work, we generate 32 high-quality reference genomes for the well-known model species D. melanogaster and focus on the identification and analysis of transposable element variation as they are the most common type of structural variant. We show that integrating the genetic variation across natural populations from five climatic regions increases the number of detected insertions by 58%. Moreover, 26% to 57% of the insertions identified using long-reads were missed by short-reads methods. We also identify hundreds of transposable elements associated with gene expression variation and new TE variants likely to contribute to adaptive evolution in this species. Our results highlight the importance of incorporating the genetic variation present in natural populations to genomic studies, which is essential if we are to understand how genomes function and evolve. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-022-29518-8 |
It is part of: | Nature Communications, 2022, vol. 13, num. 1948, p. 1-16 |
URI: | http://hdl.handle.net/2445/185555 |
Related resource: | https://doi.org/10.1038/s41467-022-29518-8 |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Publicacions de projectes de recerca finançats per la UE |
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