Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/185581
Title: | A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma |
Author: | Encinas, Cristina Hernandez Rivas, José Ángel Oriol, Albert Rosiñol, Laura Blanchard, María Jesús Bellón, José María García Sanz, Ramón Rubia, Javier de la López de la Guía, Ana Jímenez Ubieto, Ana Jarque, Isidro Iñigo, Belén Dourdil, Victoria Arriba, Felipe de Cuéllar Pérez-Ávila, Clara Gonzalez, Yolanda Hernández, Miguel Teodoro Bargay, Joan Granell, Miguel Rodríguez Otero, Paula Silvent, Maialen Cabrera, Carmen Rios, Rafael Alegre, Adrián Gironella, Mercedes Gonzalez, Marta Sonia Sureda, Anna Sampol, Antonia Ocio, Enrique M. Krsnik, Isabel García, Antonio García Mateo, Aránzazu Soler, Joan Alfons Martín, Jesús Arguiñano Pérez, José Mª Mateos, María Victoria Bladé, J. (Joan) San Miguel, Jesús F. Lahuerta, Juan José Martínez López, Joaquín Gem/pethema (Grupo Español de Mieloma/Programa para el estudio de la terapéutica en hemopatías malignas) Cooperative Study Group |
Keywords: | Mieloma múltiple Antibiòtics Multiple myeloma Antibiotics |
Issue Date: | 1-Apr-2022 |
Publisher: | Springer Science and Business Media LLC |
Abstract: | Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin <= 30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0-2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41408-022-00652-2 |
It is part of: | Blood Cancer Journal, 2022, vol. 12, num. 4 |
URI: | http://hdl.handle.net/2445/185581 |
Related resource: | https://doi.org/10.1038/s41408-022-00652-2 |
ISSN: | 2044-5385 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s41408-022-00652-2.pdf | 1.16 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License