Por favor, use este identificador para citar o enlazar este documento: https://hdl.handle.net/2445/186713
Título: Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children
Autor: Carreras Badosa, Gemma
Gómez Vilarrubla, Ariadna
Mas Pares, Berta
Xargay i Torrent, Sílvia
Prats Puig, Anna
Puerto-Carranza, Elsa
de Zegher, Francis
Ibañez Toda, Lourdes
Bassols, Judit
López Bermejo, Abel
Materia: Teixit adipós
Adolescents
Obesitat
Ronyó
Immunoglobulina A
Adipose tissues
Teenagers
Obesity
Kidney
Immunoglobulin A
Fecha de publicación: 14-sep-2021
Publicado por: Nature Publishing Group
Resumen: Both the innate and adaptive immune responses are deregulated in individuals with obesity and are key drivers of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, its mechanisms regulating the immune responses are not fully cleared. We examined whether GDF-15 was related to serum immunoglobulins in a children's cohort assessed longitudinally during childhood. Results showed that circulating GDF-15 positively associated with IgA (p < 0.002) and IgG (p < 0.001) levels and the IgA*IgG product (p < 0.001) in apparently healthy children at both baseline (age 9) and follow-up (age 13). The associations were readily observed in heavier children (those with BMI-SDS above the median) as well as in children with higher renal fat accumulation (those with renal fat-to-height ratio above the median) and remained significant after correcting for possible confounding variables. Serum GDF-15 levels accounted for up to 16% of the variance of follow-up IgG levels and up to 14% of the variance of follow-up IgA*IgG product. The longitudinal associations of the anti-inflammatory GDF-15 with IgA, IgG and the IgA*IgG product in children with higher BMI or higher renal fat accumulation suggest a role of GDF-15 in human obesity through the regulation of the immune adaptive system.
Nota: Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-97386-1
Es parte de: Scientific Reports, 2021, p. 18215-18215
URI: https://hdl.handle.net/2445/186713
Recurso relacionado: https://doi.org/10.1038/s41598-021-97386-1
ISSN: 2045-2322
Aparece en las colecciones:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

Archivos de este documento:
Archivo Descripción DimensionesFormato 
719468.pdf999.57 kBAdobe PDFMostrar/Abrir


Este documento está sujeto a una Licencia Creative Commons Creative Commons