Please use this identifier to cite or link to this item:
Title: Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix intraventricular hemorrhage.
Author: Fernández de Gamarra-Oca L
Zubiaurre Elorza, Leire
Junqué i Plaja, Carme, 1955-
Solana Díaz, Elisabeth
Soria Pastor, Sara
Vázquez, Elida
Delgado, Ignacio
Macaya Ruiz, Alfons
Ojeda, Natalia
Poca, Maria A
Keywords: Malalties cerebrals
Desenvolupament infantil
Infants prematurs
Imatges per ressonància magnètica
Brain diseases
Child development
Premature infants
Magnetic resonance imaging
Issue Date: 28-Jan-2021
Publisher: Nature Publishing Group
Abstract: Preterm newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) are at a higher risk of evidencing neurodevelopmental alterations. Present study aimed to explore the long-term efects that GM-IVH have on hippocampal subfelds, and their correlates with memory. The sample consisted of 58 participants, including 36 preterm-born (16 with GM-IVH and 20 without neonatal brain injury), and 22 full-term children aged between 6 and 15 years old. All participants underwent a cognitive assessment and magnetic resonance imaging study. GM-IVH children evidenced lower scores in Full Intelligence Quotient and memory measures compared to their low-risk preterm and full-term peers. High-risk preterm children with GM-IVH evidenced signifcantly lower total hippocampal volumes bilaterally and hippocampal subfeld volumes compared to both low-risk preterm and full-term groups. Finally, signifcant positive correlations between memory and hippocampal subfeld volumes were only found in preterm participants together; memory and the right CA-feld correlation remained signifcant after Bonferroni correction was applied (p= .002). In conclusion, memory alterations and both global and regional volumetric reductions in the hippocampus were found to be specifcally related to a preterm sample with GM-IVH. Nevertheless, results also suggest that prematurity per se has a long-lasting impact on the association between the right CA-feld volume and memory during childhood.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2021, vol. 11, p. 2420
Related resource:
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Files in This Item:
File Description SizeFormat 
712979.pdf1.24 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons