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Title: Effects of the Prior Use of Statins on Head and Neck Cancer Risk: A Hospital-Based Case–Control Study
Author: Saka Herrán, Constanza
Jané Salas, Enric
Mano Azul, Antonio
Torrejón Moya, Aina
Estrugo Devesa, Albert
López López, José, 1958-
Keywords: Càncer de cap
Càncer de coll
Factors de risc en les malalties
Head cancer
Neck cancer
Risk factors in diseases
Issue Date: 6-May-2022
Publisher: MDPI AG
Abstract: Mechanisms related to the potential beneficial effects of statins on cancer are mainly related to the inhibition of the mevalonate pathway. The purpose of this study was to assess the association between prior use of statins and the risk of head and neck cancer. A hospital-based case-control study was conducted at the Dentistry Hospital of the University of Barcelona, including 101 incident cases of head and neck cancer and 101 controls matched to cases by age and sex. Multivariate logistic regression models were used to assess the association between prior statin exposure and head and neck cancer risk. Of the 202 patients included in total, 28.2% had previously received prescriptions for statins. Prior use of statins was found in 25.7% of cases and 30.7% of controls. Exposure to statins was not associated with head and neck cancer risk (OR = 0.72; 95% CI 0.28-1.84; p = 0.49). There was also no time- or dose-dependent association. Similar trends were observed when analyzed by subsites of cancer and recurrence rate. Our findings do not support a beneficial effect of prior statin exposure on head and neck cancer risk. Future research relying on observational data should emulate randomized clinical trials before clinical implications for repurposing drugs can be drawn.
Note: Reproducció del document publicat a:
It is part of: Pharmaceuticals, 2022, vol. 15, num. 5, p. 579
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ISSN: 1424-8247
Appears in Collections:Articles publicats en revistes (Odontoestomatologia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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