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dc.contributor.authorZandi, Royacat
dc.contributor.authorReguera, D. (David)cat
dc.description.abstractViruses are known to tolerate wide ranges of pH and salt conditions and to withstand internal pressures as high as 100 atmospheres. In this paper we investigate the mechanical properties of viral capsids, calling explicit attention to the inhomogeneity of the shells that is inherent to their discrete and polyhedral nature. We calculate the distribution of stress in these capsids and analyze their response to isotropic internal pressure (arising, for instance, from genome confinement and/or osmotic activity). We compare our results with appropriate generalizations of classical (i.e., continuum) elasticity theory. We also examine competing mechanisms for viral shell failure, e.g., in-plane crack formation vs radial bursting. The biological consequences of the special stabilities and stress distributions of viral capsids are also discussed.eng
dc.format.extent12 p.-
dc.publisherThe American Physical Societyeng
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofPhysical Review e, 2004, vol. 72, núm. 2, p. 021917-1-021917-12-
dc.rights(c) American Physical Society, 2004-
dc.sourceArticles publicats en revistes (Física de la Matèria Condensada)-
dc.subject.classificationFísica mèdicacat
dc.subject.otherMedical physicseng
dc.titleMechanical properties of viral capsidseng
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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