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http://hdl.handle.net/2445/188885
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DC Field | Value | Language |
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dc.contributor.author | Leite, Diana M. | - |
dc.contributor.author | Seifi, Mohsen | - |
dc.contributor.author | Ruiz Perez, Lorena | - |
dc.contributor.author | Nguemo, Filomania | - |
dc.contributor.author | Plomann, Markus | - |
dc.contributor.author | Swinny, Jerome D. | - |
dc.contributor.author | Battaglia, Giuseppe | - |
dc.date.accessioned | 2022-09-12T09:41:17Z | - |
dc.date.available | 2022-09-12T09:41:17Z | - |
dc.date.issued | 2022-01-04 | - |
dc.identifier.issn | 2632-1297 | - |
dc.identifier.uri | http://hdl.handle.net/2445/188885 | - |
dc.description.abstract | A deficient transport of amyloid-beta across the blood-brain barrier, and its diminished clearance from the brain, contribute to neurodegenerative and vascular pathologies, such as Alzheimer's disease and cerebral amyloid angiopathy, respectively. At the blood-brain barrier, amyloid-beta efflux transport is associated with the low-density lipoprotein receptor-related protein 1. However, the precise mechanisms governing amyloid-beta transport across the blood-brain barrier, in health and disease, remain to be fully understood. Recent evidence indicates that the low-density lipoprotein receptor-related protein 1 transcytosis occurs through a tuhulation-mediated mechanism stabilized by syndapin-2. Here, we show that syndapin-2 is associated with amyloid-beta clearance via low-density lipoprotein receptor-related protein 1 across the blood-brain barrier. We further demonstrate that risk factors for Alzheimer's disease, amyloid-beta expression and ageing, are associated with a decline in the native expression of syndapin-2 within the brain endothelium. Our data reveals that syndapin-2-mediated pathway, and its balance with the endosomal sorting, are important for amyloid-beta clearance proposing a measure to evaluate Alzheimer's disease and ageing, as well as a target for counteracting amyloid-beta build-up. Moreover, we provide evidence for the impact of the avidity of amyloid-beta assemblies in their trafficking across the brain endothelium and in low-density lipoprotein receptor-related protein 1 expression levels, which may affect the overall clearance of amyloid-beta across the blood-brain barrier. | - |
dc.format.extent | 19 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/braincomms/fcac039 | - |
dc.relation.ispartof | Brain Commun, 2022, vol. 4, num. 1, p. fcac039 | - |
dc.relation.uri | https://doi.org/10.1093/braincomms/fcac039 | - |
dc.rights | cc by (c) Leite, Diana M. et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) | - |
dc.subject.classification | Malaltia d'Alzheimer | - |
dc.subject.classification | Amiloïdosi | - |
dc.subject.other | Alzheimer's disease | - |
dc.subject.other | Amyloidosis | - |
dc.title | Syndapin-2 mediated transcytosis of amyloid-beta across the blood brain barrier | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-09-12T08:12:53Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6553096 | - |
dc.identifier.pmid | 35233527 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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2022_BraCom_Syndapin_Battaglia.pdf | 2.26 MB | Adobe PDF | View/Open |
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