Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/188885
Title: | Syndapin-2 mediated transcytosis of amyloid-beta across the blood brain barrier |
Author: | Leite, Diana M. Seifi, Mohsen Ruiz Perez, Lorena Nguemo, Filomania Plomann, Markus Swinny, Jerome D. Battaglia, Giuseppe |
Keywords: | Malaltia d'Alzheimer Amiloïdosi Alzheimer's disease Amyloidosis |
Issue Date: | 4-Jan-2022 |
Abstract: | A deficient transport of amyloid-beta across the blood-brain barrier, and its diminished clearance from the brain, contribute to neurodegenerative and vascular pathologies, such as Alzheimer's disease and cerebral amyloid angiopathy, respectively. At the blood-brain barrier, amyloid-beta efflux transport is associated with the low-density lipoprotein receptor-related protein 1. However, the precise mechanisms governing amyloid-beta transport across the blood-brain barrier, in health and disease, remain to be fully understood. Recent evidence indicates that the low-density lipoprotein receptor-related protein 1 transcytosis occurs through a tuhulation-mediated mechanism stabilized by syndapin-2. Here, we show that syndapin-2 is associated with amyloid-beta clearance via low-density lipoprotein receptor-related protein 1 across the blood-brain barrier. We further demonstrate that risk factors for Alzheimer's disease, amyloid-beta expression and ageing, are associated with a decline in the native expression of syndapin-2 within the brain endothelium. Our data reveals that syndapin-2-mediated pathway, and its balance with the endosomal sorting, are important for amyloid-beta clearance proposing a measure to evaluate Alzheimer's disease and ageing, as well as a target for counteracting amyloid-beta build-up. Moreover, we provide evidence for the impact of the avidity of amyloid-beta assemblies in their trafficking across the brain endothelium and in low-density lipoprotein receptor-related protein 1 expression levels, which may affect the overall clearance of amyloid-beta across the blood-brain barrier. |
Note: | Reproducció del document publicat a: https://doi.org/10.1093/braincomms/fcac039 |
It is part of: | Brain Commun, 2022, vol. 4, num. 1, p. fcac039 |
URI: | http://hdl.handle.net/2445/188885 |
Related resource: | https://doi.org/10.1093/braincomms/fcac039 |
ISSN: | 2632-1297 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
2022_BraCom_Syndapin_Battaglia.pdf | 2.26 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License