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http://hdl.handle.net/2445/188925
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DC Field | Value | Language |
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dc.contributor.author | Climent-Cantó, Paula | - |
dc.contributor.author | Molnar, Cristina | - |
dc.contributor.author | Santabárbara-Ruiz, Paula | - |
dc.contributor.author | Prieto, Cristina | - |
dc.contributor.author | Abril Ferrando, Josep Francesc, 1970- | - |
dc.contributor.author | Serras Rigalt, Florenci | - |
dc.contributor.author | Gonzalez, Cayetano | - |
dc.date.accessioned | 2022-09-12T10:08:39Z | - |
dc.date.available | 2022-09-12T10:08:39Z | - |
dc.date.issued | 2022-08-16 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | http://hdl.handle.net/2445/188925 | - |
dc.description.abstract | The loss-of-function conditions for an l(3)malignant brain tumour (l(3)mbt) in larvae reared at 29 degrees C results in malignant brain tumours and hyperplastic imaginal discs. Unlike the former that have been extensively characterised, little is known about the latter. Here we report the results of a study of the hyperplastic l(3)mbt mutant wing imaginal discs. We identify the l(3)mbt wing disc tumour transcriptome and find it to include genes involved in reactive oxygen species (ROS) metabolism. Furthermore, we show the presence of oxidative stress in l(3)mbt hyperplastic discs, even in apoptosis-blocked conditions, but not in l(3)mbt brain tumours. We also find that chemically blocking oxidative stress in l(3)mbt wing discs reduces the incidence of wing disc overgrowths. Our results reveal the involvement of oxidative stress in l(3)mbt wing discs hyperplastic growth. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cells11162542 | - |
dc.relation.ispartof | Cells, 2022, vol. 11, num. 16, p. 2542 | - |
dc.relation.uri | https://doi.org/10.3390/cells11162542 | - |
dc.rights | cc by (c) Climent Cantó, Paula et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Drosòfila | - |
dc.subject.classification | Estrès oxidatiu | - |
dc.subject.classification | Hiperplàsia suprarenal congènita | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Tumors | - |
dc.subject.other | Drosophila | - |
dc.subject.other | Oxidative stress | - |
dc.subject.other | Congenital adrenal hyperplasia | - |
dc.subject.other | Cancer | - |
dc.subject.other | Tumors | - |
dc.title | Oxidative Stress Is Associated with Overgrowth in Drosophila l(3)mbt Mutant Imaginal Discs | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 725694 | - |
dc.date.updated | 2022-09-08T09:41:19Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36010619 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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cells-11-02542.pdf | 2.93 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License