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http://hdl.handle.net/2445/189205
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DC Field | Value | Language |
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dc.contributor.author | Zaouali, Mohamed Amine | - |
dc.contributor.author | Ben Mosbah, Ismail | - |
dc.contributor.author | Boncompagni, Eleonora | - |
dc.contributor.author | Ben Abdennebi, Hassen | - |
dc.contributor.author | Mitjavila Cors, Maria Teresa | - |
dc.contributor.author | Bartrons Bach, Ramon | - |
dc.contributor.author | Freitas, Isabel | - |
dc.contributor.author | Rimola Castellá, Antonio | - |
dc.contributor.author | Roselló Catafau, Juan | - |
dc.date.accessioned | 2022-09-21T16:50:37Z | - |
dc.date.available | 2022-09-21T16:50:37Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | http://hdl.handle.net/2445/189205 | - |
dc.description.abstract | AIM: To examine the relevance of hypoxia inducible factor (HIF-1) and nitric oxide (NO) on the preservation of fatty liver against cold ischemia-reperfusion injury (IRI). METHODS: We used an isolated perfused rat liver model and we evaluated HIF-1α in steatotic and non-steatotic livers preserved for 24 h at 4°C in University of Wisconsin and IGL-1 solutions, and then subjected to 2 h of normothermic reperfusion. After normoxic reperfusion, liver enzymes, bile production, bromosulfophthalein clearance, as well as HIF-1α and NO [endothelial NO synthase (eNOS) activity and nitrites/nitrates] were also measured. Other factors associated with the higher susceptibility of steatotic livers to IRI, such as mitochondrial damage and vascular resistance were evaluated. RESULTS: A significant increase in HIF-1α was found in steatotic and non-steatotic livers preserved in IGL-1 after cold storage. Livers preserved in IGL-1 showed a significant attenuation of liver injury and improvement in liver function parameters. These benefits were enhanced by the addition of trimetazidine (an anti-ischemic drug), which induces NO and eNOS activation, to IGL-1 solution. In normoxic reperfusion, the presence of NO favors HIF-1α accumulation, promoting also the activation of other cytoprotective genes, such as heme-oxygenase-1. CONCLUSION: We found evidence for the role of the HIF-1α/NO system in fatty liver preservation, especially when IGL-1 solution is used. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Baishideng Publishing Group Inc | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3748/wjg.v16.i28.3499 | - |
dc.relation.ispartof | World Journal of Gastroenterology, 2010, vol. 16, num. 28, p. 3499-3509 | - |
dc.relation.uri | https://doi.org/10.3748/wjg.v16.i28.3499 | - |
dc.rights | cc-by-nc (c) Zaouali, Mohamed Amine et al., 2010 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Malalties del fetge | - |
dc.subject.classification | Òxid nítric | - |
dc.subject.classification | Oxigen en l'organisme | - |
dc.subject.classification | Conservació d'òrgans | - |
dc.subject.other | Liver diseases | - |
dc.subject.other | Nitric oxide | - |
dc.subject.other | Oxygen in the body | - |
dc.subject.other | Preservation of organs | - |
dc.title | Hypoxia inducible factor-1α accumulation in steatotic liver preservation: role of nitric oxide | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 589370 | - |
dc.date.updated | 2022-09-21T16:50:38Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 20653058 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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589370.pdf | 1.5 MB | Adobe PDF | View/Open |
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