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Title: Prosthetic shoulder joint infection by Cutibacterium acnes: does rifampin improve prognosis? a retrospective, multicenter, observational study.
Author: Vilchez, Helem H.
Escudero Sánchez, Rosa
Fernandez-Sampedro, Marta
Murillo Rubio, Óscar
Auñón, Álvaro
Rodríguez-Pardo, Dolors
Jover-Sáenz, Alfredo
Del Toro, Maria Dolores
Rico, Alicia
Falgueras, Luis
Praena Segovia, Julia
Guío, Laura
Iribarren, José A.
Lora-Tamayo Morillo-Velarde, Jaime
Benito Hernández, M. Natividad de
Morata, Laura
Ramirez, Antonio
Riera, Melchor
Keywords: Bacteris anaerobis
Anaerobic bacteria
Issue Date: 21-Apr-2021
Publisher: MDPI
Abstract: This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes-related PJI (median age, 67.5 years (IQR, 57.3-75.8)); 75% were men. The majority (61.4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43.2%) included β-lactam. Thirty-four patients (87.17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6.89; 95% CI: 0.80-58.90) or prior surgery and infection (OR: 10.67; 95% IC: 1.08-105.28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40.0% vs. 8.8%). Rifampin treatment did not decrease recurrence in patients treated with β-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI.
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It is part of: Antibiotics, 2021, vol. 10, num. 5
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ISSN: 2079-6382
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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