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Title: | Prosthetic shoulder joint infection by Cutibacterium acnes: does rifampin improve prognosis? a retrospective, multicenter, observational study. |
Author: | Vilchez, Helem H. Escudero Sánchez, Rosa Fernandez-Sampedro, Marta Murillo Rubio, Óscar Auñón, Álvaro Rodríguez-Pardo, Dolors Jover-Sáenz, Alfredo Del Toro, Maria Dolores Rico, Alicia Falgueras, Luis Praena Segovia, Julia Guío, Laura Iribarren, José A. Lora-Tamayo Morillo-Velarde, Jaime Benito Hernández, M. Natividad de Morata, Laura Ramirez, Antonio Riera, Melchor |
Keywords: | Bacteris anaerobis Infeccions Cirurgia Pròtesis Anaerobic bacteria Infections Surgery Prosthesis |
Issue Date: | 21-Apr-2021 |
Publisher: | MDPI |
Abstract: | This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes-related PJI (median age, 67.5 years (IQR, 57.3-75.8)); 75% were men. The majority (61.4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43.2%) included β-lactam. Thirty-four patients (87.17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6.89; 95% CI: 0.80-58.90) or prior surgery and infection (OR: 10.67; 95% IC: 1.08-105.28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40.0% vs. 8.8%). Rifampin treatment did not decrease recurrence in patients treated with β-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/antibiotics10050475 |
It is part of: | Antibiotics, 2021, vol. 10, num. 5 |
URI: | http://hdl.handle.net/2445/189350 |
Related resource: | https://doi.org/10.3390/antibiotics10050475 |
ISSN: | 2079-6382 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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