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Title: Optimized N-methyl-D-aspartate receptor antagonist exhibits hippocampal proneurogenic effects in aged senescence-accelerated mouse prone 8 mice
Author: Companys Alemany, Júlia
Roig-Soriano, Joan
Turcu, Andreea L.
Chillón, Miguel
Vázquez Cruz, Santiago
Pallàs i Llibería, Mercè, 1964-
Griñán Ferré, Christian
Keywords: Hipocamp (Cervell)
Malalties neurodegeneratives
Hippocampus (Brain)
Neurodegenerative Diseases
Issue Date: 5-Oct-2022
Publisher: Lippincott, Williams & Wilkins
Abstract: N-methyl-D-aspartate (NMDA) receptor antagonists mediate adult neurogenic effects. Here, the neurogenic effect of a new NMDA receptor antagonist endowed with neuroprotective effects in Alzheimer's disease mice model. Nine-month-old senescence-accelerated mouse prone 8 (SAMP8) with UB-ALT-EV were orally treated. 5-Bromo-2-deoxyuridine (BrdU) (50 mg/kg) was 3× injected I.P. every 2 h. After 28 days of treatment, SAMP8-treated group improved working memory. Moreover, the number of BrdU+ cells and DCX+ cells in the SAMP8 dentate gyrus (DG) was significantly increased. GFAP+ cells were not affected by treatment. Together, these results provided evidence that UB-ALT-EV promotes the survival and proliferation of neural progenitor cells in the aged SAMP8 hippocampus.
Note: Versió postprint del document publicat a:
It is part of: NeuroReport, 2022, vol. 33, num. 4, p. 623-628
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ISSN: 0959-4965
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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