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Title: BOM-phosphinite as an electrophilic P-stereogenic transfer reagent for the synthesis of bulky phosphines. Synthesis of tert-butyl(3,5-di-tert-butylphenyl)BisP*
Author: Rojo, Pep
Riera i Escalé, Antoni
Verdaguer i Espaulella, Xavier
Keywords: Fòsfor
Química analítica
Analytical chemistry
Issue Date: 3-Jun-2021
Publisher: American Chemical Society
Abstract: BOM-tert-butylmethylphosphinite borane is an efficient electrophilic P-stereogenic transfer reagent for the synthesis of bulky tertiary phosphines. The novel methodology relies on a one-pot deprotection/substitution process. The substitution of the trivalent phosphinite takes place with high stereospecificity and provides the products with inversion of configuration at the phosphorus atom. The potential of the methodology is demonstrated with the synthesis of a wide scope of tertiary phoshines in excellent enantiomeric excess. Finally the methodology was applied to the synthesis of bulky P-stereogenic BisP* ligand analog.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2021, vol. 23, num. 12, p. 4802-4806
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ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Química Inorgànica i Orgànica)

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