Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/190046
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Muniesa Montserrat, Cristina | - |
dc.contributor.author | Gallardo, F. (Fernando) | - |
dc.contributor.author | García-Doval, Ignacio | - |
dc.contributor.author | Estrach Panella, Ma. Teresa (María Teresa) | - |
dc.contributor.author | Combalia, Andrea | - |
dc.contributor.author | Morillo, Mercedes | - |
dc.contributor.author | De la Cruz-Vicente, Fátima | - |
dc.contributor.author | Machan, Salma | - |
dc.contributor.author | Moya-Martínez, Cristina | - |
dc.contributor.author | Rovira, Roger | - |
dc.contributor.author | Sanchez-Gonzalez, Blanca | - |
dc.contributor.author | Acebo, Elvira | - |
dc.contributor.author | Amutio, Elena | - |
dc.contributor.author | Peñate, Yerai | - |
dc.contributor.author | Losada-Castillo, Maria del Carmen | - |
dc.contributor.author | Garcia-Muret, Maria P. | - |
dc.contributor.author | Iznardo, Helena | - |
dc.contributor.author | Román-Curto, Concepción | - |
dc.contributor.author | Cañueto, Javier | - |
dc.contributor.author | Fernández-de-Misa, Ricardo | - |
dc.contributor.author | Flórez, Ángeles | - |
dc.contributor.author | Izu, Rosa | - |
dc.contributor.author | Torres-Navarro, Ignacio | - |
dc.contributor.author | Zayas, Ana | - |
dc.contributor.author | Pérez-Paredes, Gema | - |
dc.contributor.author | Blanes, Mar | - |
dc.contributor.author | Yanguas, J. Ignacio | - |
dc.contributor.author | Pérez-Ferriols, Amparo | - |
dc.contributor.author | Callejas-Charavia, Marta | - |
dc.contributor.author | Ortiz-Romero, Pablo Luis | - |
dc.contributor.author | Pérez Gil, Amalia | - |
dc.contributor.author | Prieto-Torres, Lucia | - |
dc.contributor.author | González Barca, Eva | - |
dc.contributor.author | Servitje Bedate, Octavio | - |
dc.date.accessioned | 2022-10-21T16:30:56Z | - |
dc.date.available | 2023-08-05T05:10:23Z | - |
dc.date.issued | 2022-08-05 | - |
dc.identifier.issn | 0926-9959 | - |
dc.identifier.uri | http://hdl.handle.net/2445/190046 | - |
dc.description.abstract | Background: Brentuximab vedotin (BV) has been approved for CD30-expressing cutaneous T-cell lymphoma (CTCL) after at least one previous systemic treatment. However, real clinical practice is still limited. Objectives: To evaluate the response and tolerance of BV in a cohort of patients with CTCL. Methods: We analysed CTCL patients treated with BV from the Spanish Primary Cutaneous Lymphoma Registry (RELCP). Results: Sixty-seven patients were included. There were 26 females and the mean age at diagnosis was 59 years. Forty-eight were mycosis fungoides (MF), 7 Sézary syndrome (SS) and 12 CD30+ lymphoproliferative disorders (CD30 LPD). Mean follow-up was 18 months. Thirty patients (45%) showed at least 10% of CD30+ cells among the total lymphocytic infiltrate. The median number of BV infusions received was 7. The overall response rate (ORR) was 67% (63% in MF, 71% in SS and 84% in CD30 LPD). Ten of 14 patients with folliculotropic MF (FMF) achieved complete or partial response (ORR 71%). The median time to response was 2.8 months. During follow-up, 36 cases (54%) experienced cutaneous relapse or progression. The median progression free survival (PFS) was 10.3 months. The most frequent adverse event was peripheral neuropathy (PN) (57%), in most patients (85%), grades 1 or 2. Conclusions: These results confirm the efficacy and safety of BV in patients with advanced-stage MF, and CD30 LPD. In addition, patients with FMF and SS also showed a favourable response. Our data suggest that BV retreatment is effective in a proportion of cases. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1111/jdv.18563 | - |
dc.relation.ispartof | Journal of the European Academy of Dermatology and Venereology, 2022 | - |
dc.relation.uri | https://doi.org/10.1111/jdv.18563 | - |
dc.rights | (c) European Academy of Dermatology and Venereology, 2022 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Limfomes | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.classification | Quimioteràpia | - |
dc.subject.other | Lymphomas | - |
dc.subject.other | T cells | - |
dc.subject.other | Chemotherapy | - |
dc.title | Brentuximab vedotin in the treatment of cutaneous T-cell lymphomas: data from the Spanish primary cutaneous lymphoma registry | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 725957 | - |
dc.date.updated | 2022-10-21T16:30:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
725957.pdf | 213.97 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.