Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/190679
Title: | CERKL, a Retinal Dystrophy Gene, Regulates Mitochondrial Transport and Dynamics in Hippocampal Neurons. |
Author: | García-Arroyo, Rocío Marfany i Nadal, Gemma Mirra, Serena |
Keywords: | Hipocamp (Cervell) Neurones Mitocondris Hippocampus (Brain) Neurons Mitochondria |
Issue Date: | 30-Sep-2022 |
Publisher: | MDPI |
Abstract: | Mutations in the Ceramide Kinase-like (CERKL) gene cause retinal dystrophies, characterized by progressive degeneration of retinal neurons, which eventually lead to vision loss. Among other functions, CERKL is involved in the regulation of autophagy, mitochondrial dynamics, and metabolism in the retina. However, CERKL is nearly ubiquitously expressed, and it has been recently described to play a protective role against brain injury. Here we show that Cerkl is expressed in the hippocampus, and we use mouse hippocampal neurons to explore the impact of either overexpression or depletion of CERKL on mitochondrial trafficking and dynamics along axons. We describe that a pool of CERKL localizes at mitochondria in hippocampal axons. Importantly, the depletion of CERKL in the CerklKD/KO mouse model is associated with changes in the expression of fusion/fission molecular regulators, induces mitochondrial fragmentation, and impairs axonal mitochondrial trafficking. Our findings highlight the role of CERKL, a retinal dystrophy gene, in the regulation of mitochondrial health and homeostasis in central nervous system anatomic structures other than the retina. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms231911593 |
It is part of: | International Journal of Molecular Sciences, 2022, vol. 23, num. 19, p. 11593 |
URI: | http://hdl.handle.net/2445/190679 |
Related resource: | https://doi.org/10.3390/ijms231911593 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
726637.pdf | 3.68 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License