Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/190722
Title: | Ion release and local effects of titanium metal particles from dental implants: an experimental study in rats |
Author: | Toledano Serrabona, Jorge Camps Font, Octavi Pompeu de Moraes, Diogo Corte-Rodríguez, Mario Montes-Bayón, Maria Valmaseda Castellón, Eduardo Gay Escoda, Cosme Sánchez Garcés, Ma. Ángeles |
Keywords: | Experimentació animal Implants dentals Titani Maxil·lars Animal experimentation Dental implants Titanium Jaws |
Issue Date: | 9-Jun-2022 |
Publisher: | American Academy of Periodontology |
Abstract: | Background: The objective of this study was to evaluate the accumulation of ions in blood and organs caused by Ti metal particles in a mandibular defect in rats, together with a description of the local reaction of oral tissues to these titanium alloy debris. Methods: Twenty Sprague-Dawley rats were randomly distributed into three groups: an experimental group with a mandibular bone defect filled with metallic debris obtained by implantoplasty; a positive control group; and a negative control group. Thirty days after surgery, the rats were euthanized and perilesional tissue surrounding the mandibular defect was removed, together with the lungs, spleen, liver and brain. Two blood samples were collected: immediately before surgery and before euthanasia. The perilesional tissue was histologically analyzed using hematoxylin-eosin staining, and titanium, aluminum and vanadium ion concentrations in blood and organs were measured by TQ-ICP-MS. Descriptive and bivariate analyses of the data were performed. Results: All rats with implanted metal debris showed metal particles and a bone fracture callus on the osseous defect. The metal particles were surrounded by a foreign body reaction characterized by the presence of histiocytes and multinucleated giant cells. The experimental group had a significant higher concentration of Ti ions in all studied organs except lung tissue (p < 0.05). In addition, there were more V ions in the brain in the experimental group (p = 0.008). Conclusions: Although further studies are required to confirm the clinical relevance of these results, Ti metal particles in the jaw might increase the concentration of metal ions in vital organs and induce a foreign body reaction. This article is protected by copyright. All rights reserved. Keywords: Ion release; Ti6Al4V; implantoplasty; metal particles; peri-implantitis; titanium. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/JPER.22-0091 |
It is part of: | Journal of Periodontology, 2022 |
URI: | http://hdl.handle.net/2445/190722 |
Related resource: | https://doi.org/10.1002/JPER.22-0091 |
ISSN: | 0022-3492 |
Appears in Collections: | Articles publicats en revistes (Odontoestomatologia) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
724265.pdf | 3.23 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License