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Title: Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study
Author: Cañete-Massé, Cristina
Carbó-Carreté, Maria
Peró, Maribel
Cui, Shi Xian
Yan, Chao Gan
Guàrdia-Olmos, Joan, 1958-
Keywords: Síndrome de Down
Mapatge del cervell
Imatges per ressonància magnètica
Down syndrome
Brain mapping
Magnetic resonance imaging
Issue Date: 6-Oct-2022
Publisher: Elsevier España
Abstract: Background/Objective: Neuroimaging studies have shown brain abnormalities in Down syndrome (DS) but have not clarified the underlying mechanisms of dysfunction. Here, we investigated the degree centrality (DC) abnormalities found in the DS group compared with the control group, and we conducted seed-based functional connectivity (FC) with the significant clusters found in DC. Moreover, we used the significant clusters of DC and the seed-based FC to elucidate differences between brain networks in DS compared with controls. Method: The sample comprised 18 persons with DS (M = 28.67, SD = 4.18) and 18 controls (M = 28.56, SD = 4.26). Both samples underwent resting-state functional magnetic resonance imaging. Results: DC analysis showed increased DC in the DS in temporal and right frontal lobe, as well as in the left caudate and rectus and decreased DC in the DS in regions of the left frontal lobe. Regarding seed-based FC, DS showed increased and decreased FC. Significant differences were also found between networks using Yeo parcellations, showing both hyperconnectivity and hypoconnectivity between and within networks. Conclusions: DC, seed-based FC and brain networks seem altered in DS, finding hypo- and hyperconnectivity depending on the areas. Network analysis revealed between- and within-network differences, and these abnormalities shown in DS could be related to the characteristics of the population.
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It is part of: International Journal of Clinical And Health Psychology, 2022, vol. 23, num. 1, p. 100341
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ISSN: 1697-2600
Appears in Collections:Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)
Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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