Please use this identifier to cite or link to this item:
Title: Malignant transformation rate of oral submucous fibrosis: a systematic review and meta-analysis
Author: Murthy, Vignesh
Mylonas, Petros
Carey, Barbara
Yogarajah, Sangeetha
Farnell, Damian
Addison, Owen
Cook, Richard
Escudier, Michael
Diniz-Freitas, Marcio
Limeres, Jacobo
Monteiro, Luis
Silva, Luis
Fricain, Jean-Cristophe
Catros, Sylvain
Fenelon, Mathilde
Lodi, Giovanni
Lombardi, Niccolò
Brailo, Vlaho
Ariyaratnam, Raj
López López, José, 1958-
Alburquerque, Rui
Keywords: Càncer de boca
Oral cancer
Issue Date: 24-Mar-2022
Publisher: MDPI
Abstract: Oral submucous fibrosis (OSF) is a chronic progressive condition affecting the oral cavity, oropharynx and upper third of the oesophagus. It is a potentially malignant disorder. The authors collated and analysed the existing literature to establish the overall malignant transformation rate (MTR). A retrospective analysis of medical and dental scientific literature using online indexed databases was conducted for the period 1956 to 2021. The quality of the enrolled studies was assessed by the Newcastle-Ottawa Scale (NOS). A meta-analysis using a random effects model of a single proportion was performed along with statistical tests for heterogeneity. The overall proportion of malignancy across all studies was 0.06 (95% CI, 0.02-0.10), indicating an overall 6% risk of malignant transformation across all studies and cohorts. Sub-group analyses revealed strong differences in proportion of malignancy according to ethnicity/cohort; Chinese = 0.02 (95% CI 0.01-0.02), Taiwanese = 0.06 (95% CI, 0.03-0.10), Indian = 0.08 (95% CI, 0.03-0.14) and Pakistani = 0.27 (95% CI 0.25-0.29). Overall, the MTR was 6%; however, wide heterogeneity of the included studies was noted. Geographic variations in MTR were noted but were not statistically significant. Further studies are required to analyse the difference between cohort groups
Note: Reproducció del document publicat a:
It is part of: Journal of Clinical Medicine, 2022, vol. 11, num. 7, p. 1793
Related resource:
ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (Odontoestomatologia)

Files in This Item:
File Description SizeFormat 
724454.pdf2.06 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons