Please use this identifier to cite or link to this item:
Title: A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging
Author: Fernandez, Antonio
Kielland, Nicola
Makda, Ashraff
Carragher, Neil
González-García, M. Carmen
Espinar-Barranco, Laura
González-Vera, Juan Antonio
Orte, Ángel
Lavilla Grífols, Rodolfo
Vendrell, Marc
Keywords: Química farmacèutica
Síntesi orgànica
Pharmaceutical chemistry
Organic synthesis
Issue Date: 28-Aug-2022
Publisher: MDPI
Abstract: We report a platform combining multicomponent reaction synthesis and automated cell-based screening to develop biocompatible NIR-BODIPY fluorophores. From a library of over 60 fluorophores, we optimised compound NIRBD-62c as a multimodal probe with suitable properties for STED super-resolution and fluorescence lifetime imaging. Furthermore, we employed NIRBD-62c for imaging trafficking inside cells and to examine how pharmacological inhibitors can alter the vesicular traffic between intracellular compartments and the plasma membrane.
Note: Reproducció del document publicat a:
It is part of: Biomedicines, 2022
Related resource:
ISSN: 2227-9059
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Files in This Item:
File Description SizeFormat 
724484.pdf2.93 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons