Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/192271
Title: | Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome |
Author: | Valle-Hita, Cristina Becerra Tomás, Nerea Díaz López, Andrés Vázquez Ruiz, Zenaida Megías, Isabel Corella Piquer, Dolores Goday Arnó, Albert Martínez, J. Alfredo, 1957- Alonso Gómez, Ángel M. Wärnberg, Julia Vioque, Jesús Romaguera, Dora López Miranda, José Estruch Riba, Ramon Tinahones, Francisco J. Lapetra, José Serra Majem, Lluís Bueno-Cavanillas, Aurora Tur, Josep Antoni Martín-Sánchez, Vicente Pintó Sala, Xavier Gaforio, José J. Matía Martín, Pilar Vidal i Cortada, Josep Amengual-Galbarte, Angela Daimiel, Lidia Ros Rahola, Emilio Garcia-Arellano, Ana Barragán, Rocío Fitó Colomer, Montserrat Peña Orihuela, Patricia J. Asencio, Alberto Gómez Gracia, Enrique Martinez Urbistondo, Diego Morey, Marga Casas, Rosa Garrido-Garrido, Eva Maria Tojal Sierra, Lucas Damas-Fuentes, Miguel Goñi, Estibaliz Ortega Azorín, Carolina Castañer, Olga Garcia-Rios, Antonio Gisbert Sellés, Cristina Sayón Orea, Carmen Schröder, Helmut, 1958- Salas Salvadó, Jordi Babio, Nancy |
Keywords: | Malalties del ronyó Síndrome metabòlica Nutrició Kidney diseases Metabolic syndrome Nutrition |
Issue Date: | 30-Sep-2022 |
Publisher: | Frontiers Media |
Abstract: | Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: -0.64 ml/min/1.73 m2; 95% CI: -1.21 to -0.08 and NEAP, β: -0.56 ml/min/1.73 m2; 95% CI: -1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07-1.54 and NEAP, OR: 1.24; 95% CI: 1.03-1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04-1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome. Keywords: albuminuria; chronic kidney disease (CKD); dietary acid load; glomerular filtration rate (GFR); kidney function; net endogenous acid production (NEAP); potential renal acid load (PRAL); renal nutrition. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fnut.2022.986190 |
It is part of: | Frontiers In Nutrition, 2022, vol. 9, p. 986190 |
URI: | https://hdl.handle.net/2445/192271 |
Related resource: | https://doi.org/10.3389/fnut.2022.986190 |
ISSN: | 2296-861X |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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