Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/192271
Title: Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome
Author: Valle-Hita, Cristina
Becerra Tomás, Nerea
Díaz López, Andrés
Vázquez Ruiz, Zenaida
Megías, Isabel
Corella Piquer, Dolores
Goday Arnó, Albert
Martínez, J. Alfredo, 1957-
Alonso Gómez, Ángel M.
Wärnberg, Julia
Vioque, Jesús
Romaguera, Dora
López Miranda, José
Estruch Riba, Ramon
Tinahones, Francisco J.
Lapetra, José
Serra Majem, Lluís
Bueno-Cavanillas, Aurora
Tur, Josep Antoni
Martín-Sánchez, Vicente
Pintó Sala, Xavier
Gaforio, José J.
Matía Martín, Pilar
Vidal i Cortada, Josep
Amengual-Galbarte, Angela
Daimiel, Lidia
Ros Rahola, Emilio
Garcia-Arellano, Ana
Barragán, Rocío
Fitó Colomer, Montserrat
Peña Orihuela, Patricia J.
Asencio, Alberto
Gómez Gracia, Enrique
Martinez Urbistondo, Diego
Morey, Marga
Casas, Rosa
Garrido-Garrido, Eva Maria
Tojal Sierra, Lucas
Damas-Fuentes, Miguel
Goñi, Estibaliz
Ortega Azorín, Carolina
Castañer, Olga
Garcia-Rios, Antonio
Gisbert Sellés, Cristina
Sayón Orea, Carmen
Schröder, Helmut, 1958-
Salas Salvadó, Jordi
Babio, Nancy
Keywords: Malalties del ronyó
Síndrome metabòlica
Nutrició
Kidney diseases
Metabolic syndrome
Nutrition
Issue Date: 30-Sep-2022
Publisher: Frontiers Media
Abstract: Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: -0.64 ml/min/1.73 m2; 95% CI: -1.21 to -0.08 and NEAP, β: -0.56 ml/min/1.73 m2; 95% CI: -1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07-1.54 and NEAP, OR: 1.24; 95% CI: 1.03-1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04-1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome. Keywords: albuminuria; chronic kidney disease (CKD); dietary acid load; glomerular filtration rate (GFR); kidney function; net endogenous acid production (NEAP); potential renal acid load (PRAL); renal nutrition.
Note: Reproducció del document publicat a: https://doi.org/10.3389/fnut.2022.986190
It is part of: Frontiers In Nutrition, 2022, vol. 9, p. 986190
URI: http://hdl.handle.net/2445/192271
Related resource: https://doi.org/10.3389/fnut.2022.986190
ISSN: 2296-861X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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