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DC Field | Value | Language |
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dc.contributor.author | Vilà-Balló, Adrià | - |
dc.contributor.author | De La Cruz Puebla, Myriam | - |
dc.contributor.author | López Barroso, Diana | - |
dc.contributor.author | Miró, Júlia | - |
dc.contributor.author | Sala Padró, Jacint | - |
dc.contributor.author | Cucurell, David | - |
dc.contributor.author | Falip, Mercè | - |
dc.contributor.author | Rodríguez Fornells, Antoni | - |
dc.date.accessioned | 2023-01-18T17:54:08Z | - |
dc.date.available | 2023-01-18T17:54:08Z | - |
dc.date.issued | 2022-01-01 | - |
dc.identifier.issn | 2213-1582 | - |
dc.identifier.uri | http://hdl.handle.net/2445/192295 | - |
dc.description.abstract | Background: Correct functioning of the reward processing system is critical for optimizing decision-making as well as preventing the development of addictions and/or neuropsychiatric symptoms such as depression, apathy, and anhedonia. Consequently, patients with mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis (mTLE-UHS) represent an excellent opportunity to study the brain networks involved in this system. Objective: The aim of the current study was to evaluate decision-making and the electrophysiological correlates of feedback processing in a sample of mTLE-UHS patients, compared to healthy controls. In addition, we assessed the impact of mesial temporal lobe surgical resection on these processes, as well as general, neuropsychological functioning. Method: 17 mTLE-UHS patients and 17 matched healthy controls completed: [1] a computerized version of the Game of Dice Task, [2] a Standard Iowa Gambling Task, and [3] a modified ERP version of a probabilistic gambling task coupled with multichannel electroencephalography. Neuropsychological scores were also obtained both pre- and post-surgery. Results: Behavioral analyses showed a pattern of increased risk for the mTLE-UHS group in decision-making under ambiguity compared to the control group. A decrease in the amplitude of the Feedback Related Negativity (FRN), a weaker effect of valence on delta power, and a general reduction of delta and theta power in the mTLE-UHS group, as compared to the control group, were also found. The beta-gamma activity associated with the delivery of positive reward was similar in both groups. Behavioral performance and electrophysiological measures did not worsen post-surgery. Conclusions: Patients with mTLE-UHS showed impairments in decision-making under ambiguity, particularly when they had to make decisions based on the outcomes of their choices, but not in decision-making under risk. No group differences were observed in decision-making when feedbacks were random. These results might be explained by the abnormal feedback processing seen in the EEG activity of patients with mTLE-UHS, and by concomitant impairments in working memory, and memory. These impairments may be linked to the disruption of mesial temporal lobe networks. Finally, feedback processing and decision-making under ambiguity were already affected in mTLE-UHS patients pre-surgery and did not show evidence of clear worsening post-surgery. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.nicl.2022.103251 | - |
dc.relation.ispartof | NeuroImage: Clinical, 2022, vol. 36, p. 103251 | - |
dc.relation.uri | https://doi.org/10.1016/j.nicl.2022.103251 | - |
dc.rights | cc by-nc-nd (c) Vilà-Balló, Adrià et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) | - |
dc.subject.classification | Toma de decisiones | - |
dc.subject.classification | Malalties cerebrals | - |
dc.subject.other | Decision making | - |
dc.subject.other | Brain diseases | - |
dc.title | Reward-based decision-making in mesial temporal lobe epilepsy patients with unilateral hippocampal sclerosis pre- and post-surgery | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-01-16T10:52:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36510413 | - |
Appears in Collections: | Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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1-s2.0-S2213158222003163-main.pdf | 5.52 MB | Adobe PDF | View/Open |
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