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Title: Fiber-like Action of D-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats
Author: Ramos Romero, Sara
Ponomarenko, Julia
Amézqueta, Susana
Hereu, Mercè
Miralles Pérez, Bernat
Romeu Ferran, Marta
Méndez, Lucía
Medina, Isabel
Torres, Josep Lluís
Keywords: Inflamació
Pes corporal
Body weight
Issue Date: 3-Nov-2022
Publisher: MDPI
Abstract: The goal of this work is to explore if the changes induced by D-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a standard diet supplemented with D-fagomine (or not, for comparison) for 6 months. The variables measured were body weight, plasma mediators of inflammation (hydroxyeicosatetraenoic acids, leukotriene B4, and IL-6), and the concentration of acetic acid in feces and plasma. The composition and diversities of microbiota in cecal content and feces were estimated using 16S rRNA metabarcoding and high-throughput sequencing. We found that after just 6 weeks of intake D-fagomine significantly reduced body weight gain, increased the plasma acetate concentration, and reduced the plasma concentration of the pro-inflammatory biomarkers' leukotriene B4, interleukin 6 and 12 hydroxyeicosatetraenoic acids. These changes were associated with a significantly increased prevalence of Bacteroides and Prevotella feces and increased Bacteroides, Prevotella, Clostridium, and Dysgonomonas while reducing Anaerofilum, Blautia, and Oribacterium in cecal content. In conclusion, D-fagomine induced changes in the composition and diversity of gut microbiota similar to those elicited by dietary fiber and compatible with its anti-inflammatory and body-weight-reducing effects.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2022, vol. 14, num. 21, p. 4656
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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