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Title: The role of the anterior insular cortex in self-monitoring: a novel study protocol with electrical stimulation mapping and functional magnetic resonance imaging
Author: Gomez-Andres, Alba
Cunillera, Toni
Rico-Pons, Imma
Naval Baudin, Pablo
Camins, Angels
Fernandez-Coello, Alejandro
Gabarrós, Andreu
Rodríguez Fornells, Antoni
Keywords: Imatges per ressonància magnètica
Mapatge del cervell
Cirurgia cerebral
Escorça cerebral
Magnetic resonance imaging
Brain mapping
Cerebral surgery
Cerebral cortex
Issue Date: 4-Oct-2022
Publisher: Elsevier Masson SAS
Abstract: Becoming aware of one's own states is a fundamental aspect for self-monitoring, allowing us to adjust our beliefs of the world to the changing context. Previous evidence points out to the key role of the anterior insular cortex (aIC) in evaluating the consequences of our own actions, especially whenever an error has occurred. In the present study, we propose a new multimodal protocol combining electrical stimulation mapping (ESM) and functional magnetic resonance imaging (fMRI) to explore the functional role of the aIC for self-monitoring in patients undergoing awake brain surgery. Our results using a modified version of the Stroop task tackling metacognitive abilities revealed new direct evidence of the involvement of the aIC in monitoring our performance, showing increased difficulties in detecting action-outcome mismatches when stimulating a cortical site located at the most posterior part of the aIC as well as significant BOLD activations at this region during outcome incongruences for self-made actions. Based on these preliminary results, we highlight the importance of assessing the aIC's functioning during tumor resection involving this region to evaluate metacognitive awareness of the self in patients undergoing awake brain surgery. In a similar vein, a better understanding of the aIC's role during self-monitoring may help shed light on action/outcome processing abnormalities reported in several neuropsychiatric disorders such as schizophrenia, anosognosia for hemiplegia or major depression.
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It is part of: Cortex, 2022, vol. 157, p. 231-244
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ISSN: 0010-9452
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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