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Title: Pathogenicity and virulence of Hepatitis A virus.
Author: Pintó Solé, Rosa María
Pérez-Rodríguez, Francisco-Javier
Costafreda Salvany, M. Isabel (Maria Isabel)
Chavarria-Miró, Gemma
Guix Arnau, Susana
Ribes Mora, Enric
Bosch, Albert
Keywords: Hepatitis A
Virus de l'hepatitis A
Malalties del fetge
Malalties dels infants
Hepatitis A
Hepatitis A virus
Liver diseases
Children's diseases
Issue Date: 2021
Publisher: Taylor and Francis
Abstract: Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or even a fulminant form. The reason for these different outcomes is unknown, but it is generally accepted that host factors such as the immunological status, age and the occurrence of underlaying hepatic diseases are the main determinants of the severity. However, it cannot be ruled out that some virus traits may also contribute to the severe clinical outcomes. In this review, we will analyze which genetic determinants of the virus may determine virulence, in the context of a paradigmatic virus in terms of its genomic, molecular, replicative, and evolutionary features
Note: Reproducció del document publicat a:
It is part of: Virulence, 2021, vol. 12, num. 1, p. 1174-1185
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ISSN: 2150-5594
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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