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http://hdl.handle.net/2445/193696
Title: | Pathogenicity and virulence of Hepatitis A virus. |
Author: | Pintó Solé, Rosa María Pérez-Rodríguez, Francisco-Javier Costafreda Salvany, M. Isabel (Maria Isabel) Chavarria-Miró, Gemma Guix Arnau, Susana Ribes Mora, Enric Bosch, Albert |
Keywords: | Hepatitis A Virus de l'hepatitis A Malalties del fetge Malalties dels infants Virus Hepatitis A Hepatitis A virus Liver diseases Children's diseases Viruses |
Issue Date: | 2021 |
Publisher: | Taylor and Francis |
Abstract: | Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or even a fulminant form. The reason for these different outcomes is unknown, but it is generally accepted that host factors such as the immunological status, age and the occurrence of underlaying hepatic diseases are the main determinants of the severity. However, it cannot be ruled out that some virus traits may also contribute to the severe clinical outcomes. In this review, we will analyze which genetic determinants of the virus may determine virulence, in the context of a paradigmatic virus in terms of its genomic, molecular, replicative, and evolutionary features |
Note: | Reproducció del document publicat a: https://doi.org/10.1080/21505594.2021.1910442 |
It is part of: | Virulence, 2021, vol. 12, num. 1, p. 1174-1185 |
URI: | http://hdl.handle.net/2445/193696 |
Related resource: | https://doi.org/10.1080/21505594.2021.1910442 |
ISSN: | 2150-5594 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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