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http://hdl.handle.net/2445/193860
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DC Field | Value | Language |
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dc.contributor.author | Guo, Longhua | - |
dc.contributor.author | Bloom, Joshua S. | - |
dc.contributor.author | Dols-Serrate, Daniel | - |
dc.contributor.author | Boocock, James | - |
dc.contributor.author | Ben David, Eyal | - |
dc.contributor.author | Schubert, Olga T. | - |
dc.contributor.author | Kozuma, Kaiya | - |
dc.contributor.author | Ho, Katarina | - |
dc.contributor.author | Warda, Emily | - |
dc.contributor.author | Chui, Clarice | - |
dc.contributor.author | Wei, Yubao | - |
dc.contributor.author | Leighton, Daniel | - |
dc.contributor.author | Lemus Vergara, Tzitziki | - |
dc.contributor.author | Riutort León, Marta | - |
dc.contributor.author | Sánchez Alvarado, Alejandro | - |
dc.contributor.author | Kruglyak, Leonid | - |
dc.date.accessioned | 2023-02-20T08:40:57Z | - |
dc.date.available | 2023-02-20T08:40:57Z | - |
dc.date.issued | 2022-06-01 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/2445/193860 | - |
dc.description.abstract | The sexual strain of the planarian Schmidtea mediterranea, indigenous to Tunisia and several Mediterranean islands, is a hermaphrodite1,2 . Here we isolate individual chromosomes and use sequencing, Hi-C3,4 and linkage mapping to assemble a chromosome-scale genome reference. The linkage map reveals an extremely low rate of recombination on chromosome 1. We confrm suppression of recombination on chromosome 1 by genotyping individual sperm cells and oocytes. We show that previously identifed genomic regions that maintain heterozygosity even after prolonged inbreeding make up essentially all of chromosome 1. Genome sequencing of individuals isolated in the wild indicates that this phenomenon has evolved specifcally in populations from Sardinia and Corsica. We fnd that most known master regulators5-13 of the reproductive system are located on chromosome 1. We used RNA interference14,15 to knock down a gene with haplotype-biased expression, which led to the formation of a more pronounced female mating organ. On the basis of these observations, we propose that chromosome 1 is a sex-primed autosome primed for evolution into a sex chromosome | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41586-022-04757-3 | - |
dc.relation.ispartof | Nature, 2022, vol. 606, p. 329-334 | - |
dc.relation.uri | https://doi.org/10.1038/s41586-022-04757-3 | - |
dc.rights | cc by (c) Guo, Longhua et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Planària (Gènere) | - |
dc.subject.classification | Genòmica | - |
dc.subject.classification | Reproducció | - |
dc.subject.other | Planaria (Genus) | - |
dc.subject.other | Genomics | - |
dc.subject.other | Reproduction | - |
dc.title | Island-specific evolution of a sex-primed autosome in a sexual planarian | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 729315 | - |
dc.date.updated | 2023-02-20T08:40:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35650439 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca de la Biodiversitat (IRBio)) Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
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729315.pdf | 10.85 MB | Adobe PDF | View/Open |
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