Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/193936
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ying, Kejun | - |
dc.contributor.author | Zhai, Ranran | - |
dc.contributor.author | Pyrkov, Timothy V. | - |
dc.contributor.author | Shindyapina, Anastasia V. | - |
dc.contributor.author | Mariotti, Marco, 1984- | - |
dc.contributor.author | Fedichev, Peter O. | - |
dc.contributor.author | Shen, Xia | - |
dc.contributor.author | Gladyshev, Vadim N. | - |
dc.date.accessioned | 2023-02-22T15:52:57Z | - |
dc.date.available | 2023-02-22T15:52:57Z | - |
dc.date.issued | 2021-10-05 | - |
dc.identifier.issn | 2730-664X | - |
dc.identifier.uri | http://hdl.handle.net/2445/193936 | - |
dc.description.abstract | Background: Epidemiological studies revealed that the elderly and those with comorbidities are most affected by COVID-19, but it is important to investigate shared genetic mechanisms between COVID-19 risk and aging. Methods: We conducted a multi-instrument Mendelian Randomization analysis of multiple lifespan-related traits and COVID-19. Aging clock models were applied to the subjects with different COVID-19 conditions in the UK-Biobank cohort. We performed a bivariate genomic scan for age-related COVID-19 and Mendelian Randomization analysis of 389 immune cell traits to investigate their effect on lifespan and COVID-19 risk. Results: We show that the genetic variation that supports longer life is significantly associated with the lower risk of COVID-19 infection and hospitalization. The odds ratio is 0.31 (P = 9.7 × 10-6) and 0.46 (P = 3.3 × 10-4), respectively, per additional 10 years of life. We detect an association between biological age acceleration and future incidence and severity of COVID-19 infection. Genetic profiling of age-related COVID-19 infection indicates key contributions of Notch signaling and immune system development. We reveal a negative correlation between the effects of immune cell traits on lifespan and COVID-19 risk. We find that lower B-cell CD19 levels are indicative of an increased risk of COVID-19 and decreased life expectancy, which is further validated by COVID-19 clinical data. Conclusions: Our analysis suggests that the factors that accelerate aging lead to an increased COVID-19 risk and point to the importance of Notch signaling and B cells in both. Interventions that target these factors to reduce biological age may reduce the risk of COVID-19. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s43856-021-00033-z | - |
dc.relation.ispartof | Communications medicine, 2021, vol. 1, p. 1-15 | - |
dc.relation.uri | https://doi.org/10.1038/s43856-021-00033-z | - |
dc.rights | cc-by (c) Ying, Kejun et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Envelliment | - |
dc.subject.classification | Malalties hereditàries | - |
dc.subject.classification | Malalties víriques | - |
dc.subject.other | Aging | - |
dc.subject.other | Genetic diseases | - |
dc.subject.other | Virus diseases | - |
dc.title | Genetic and phenotypic analysis of the causal relationship between aging and COVID-19 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 716273 | - |
dc.date.updated | 2023-02-22T15:52:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
716273.pdf | 2.61 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License