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Title: Microbial Phenolic Metabolites in Urine Are Inversely Linked to Certain Features of Metabolic Syndrome in Spanish Adolescents
Author: Laveriano Santos, Emily Pilar
Quifer Rada, Paola
Marhuenda-Muñoz, María
Arancibia Riveros, Camila
Vallverdú i Queralt, Anna
Tresserra i Rimbau, Anna
Ruíz León, Ana María
Casas, Rosa
Estruch Riba, Ramon
Bodega, Patricia
Miguel, Mercedes de
Cos Gandoy, Amaya de
Martínez Gomez, Jesús
Santos-Beneit, Gloria
Fernández Alvira, Juan Miguel
Fernández Jiménez, Rodrigo
Lamuela Raventós, Rosa Ma.
Keywords: Microbiota intestinal
Síndrome metabòlica
Gastrointestinal microbiome
Metabolic syndrome
Issue Date: 1-Nov-2022
Publisher: MDPI
Abstract: (1) Background: To explore the association between microbial phenolic metabolites (MPM) and metabolic syndrome (MetS) and its clinical features in adolescents aged 12.02 ± 0.41 years. (2) Methods: a cross-sectional study was conducted in 560 participants at baseline in the SI! Program for Secondary Schools trial. The following MPM, coumaric acids (m-, o-, p-coumaric acids), dihydroxyphenylpropionic acid, dihydroresveratrol, enterolignans, gallic acid, hydroxybenzoic acids, hydroxyphenylacetic acid, hydroxytyrosol, protocatechuic acid, syringic acid, urolithins (A, B), and vanillic acid, were analyzed by HPLC-LTQ-Orbitrap-HRMS. MetS and its clinical features were defined in accordance with the International Diabetes Federation. (3) Results: Out of all MPM, urolithin A was inversely associated with the diastolic blood pressure z-score. Urolithin B was inversely associated with the MetS score and waist circumference z-score. Additionally, higher levels of gallic acid were associated with lower odds of presenting MetS (OR = 0.85, 95% CI: 0.77; 0.93) and abdominal obesity (OR = 0.93, 95% CI: 0.89; 0.98). Higher urolithin B levels were inversely associated with abdominal obesity (OR = 0.94, 95% CI: 0.89; 0.98) and high blood glucose (OR = 0.92, 95% CI:0.88; 0.96); (4) Conclusions: gallic acid, urolithin A and B were associated with lower odds of presenting MetS or some of its clinical features in adolescents. This is the first study that evaluates several MPM with MetS in adolescents, highlighting the importance of MPM on cardiometabolic health at early life stages. © 2022 by the authors.
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It is part of: Antioxidants, 2022, vol. 11, num. 11
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ISSN: 2076-3921
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Medicina)

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