Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/193992
Title: Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites
Author: Bullón Vela, Vanessa
Xu, Yifan
Razquín, Cristina
Abete, Itziar
Zulet, M. Angeles
Martínez González, Miguel A.
Buil Cosiales, Pilar
Vitelli Storelli, Facundo
Martín Sánchez, Vicente
Vázquez Ruiz, Zenaida
Sayón Orea, Carmen
Domínguez-Fernández, Maite
Cid, Concepción
Estruch Riba, Ramon
Lamuela Raventós, Rosa Ma.
Fitó Colomer, Montserrat
Blanchart, Gemma
Babio, Nancy
Salas Salvadó, Jordi
Tinahones, Francisco J.
Tur, Josep Antoni
Romaguera, Dora
Konieczna, Jadwiga
Pintó Sala, Xavier
Daimiel, Lidia
Rodríguez-Mateos, Ana
Martínez, José Alfredo
Keywords: Malalties del fetge
Flavonoides
Liver diseases
Flavonoids
Issue Date: 1-Dec-2022
Publisher: Royal Society of Chemistry
Abstract: Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.
Note: Reproducció del document publicat a: https://doi.org/10.1039/d2fo02846h
It is part of: Food & Function, 2022
URI: http://hdl.handle.net/2445/193992
Related resource: https://doi.org/10.1039/d2fo02846h
ISSN: 2042-6496
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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