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Title: | Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites |
Author: | Bullón Vela, Vanessa Xu, Yifan Razquín, Cristina Abete, Itziar Zulet, M. Angeles Martínez González, Miguel A. Buil Cosiales, Pilar Vitelli Storelli, Facundo Martín Sánchez, Vicente Vázquez Ruiz, Zenaida Sayón Orea, Carmen Domínguez-Fernández, Maite Cid, Concepción Estruch Riba, Ramon Lamuela Raventós, Rosa Ma. Fitó Colomer, Montserrat Blanchart, Gemma Babio, Nancy Salas Salvadó, Jordi Tinahones, Francisco J. Tur, Josep Antoni Romaguera, Dora Konieczna, Jadwiga Pintó Sala, Xavier Daimiel, Lidia Rodríguez-Mateos, Ana Martínez, José Alfredo |
Keywords: | Malalties del fetge Flavonoides Liver diseases Flavonoids |
Issue Date: | 1-Dec-2022 |
Publisher: | Royal Society of Chemistry |
Abstract: | Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity. |
Note: | Reproducció del document publicat a: https://doi.org/10.1039/d2fo02846h |
It is part of: | Food & Function, 2022 |
URI: | http://hdl.handle.net/2445/193992 |
Related resource: | https://doi.org/10.1039/d2fo02846h |
ISSN: | 2042-6496 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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