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http://hdl.handle.net/2445/194686
Title: | Utilization of selenocysteine in early-branching fungal phyla. |
Author: | Mariotti, Marco, 1984 Salinas, Gustavo Gabaldón, Toni Gladyshev, Vadim N. |
Keywords: | Patologia vegetal Genòmica Aminoàcids Plant pathology Genomics Amino acids |
Issue Date: | May-2019 |
Publisher: | Springer Nature |
Abstract: | Selenoproteins are a diverse group of proteins containing selenocysteine (Sec)¿the twenty-first amino acid¿incorporated during translation via a unique recoding mechanism. Selenoproteins fulfil essential roles in many organisms, yet are not ubiquitous across the tree of life. In particular, fungi were deemed devoid of selenoproteins. However, we show here that Sec is utilized by nine species belonging to diverse early-branching fungal phyla, as evidenced by the genomic presence of both Sec machinery and selenoproteins. Most fungal selenoproteins lack consensus Sec recoding signals (SECIS elements) but exhibit other RNA structures, suggesting altered mechanisms of Sec insertion in fungi. Phylogenetic analyses support a scenario of vertical inheritance of the Sec trait within eukaryotes and fungi. Sec was then lost in numerous independent events in various fungal lineages. Notably, Sec was lost at the base of Dikarya, resulting in the absence of selenoproteins in Saccharomyces cerevisiae and other well-studied fungi. Our results indicate that, despite scattered occurrence, selenoproteins are found in all kingdoms of life. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/s41564-018-0354-9 |
It is part of: | Nature Microbiology, 2019, vol. 4, num. 5, p. 759-765 |
URI: | http://hdl.handle.net/2445/194686 |
Related resource: | https://doi.org/10.1038/s41564-018-0354-9 |
ISSN: | 2058-5276 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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