Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/194702
Title: | Relationship between the ABO blood group and COVID-19 susceptibility, severity and mortality in two cohorts of patients |
Author: | Muñiz-Diaz, Eduardo Llopis Pérez, Jaime Parra, Rafael Roig, Imma Ferrer, Gonzalo Grifols, Joan Millán, Anna Ene, Gabriela Ramiro, Laia Maglio, Laura García, Nadia Pinacho, Asunción Jaramillo, Anny Peró, Agustí Artaza, Gonzalo Vallés, Roser Sauleda, Silvia Puig, Lluís Contreras, Enric |
Keywords: | Grups sanguinis COVID-19 Genètica Mortalitat Blood groups COVID-19 Genetics Mortality |
Issue Date: | 12-Nov-2020 |
Publisher: | Edizioni SIMTI |
Abstract: | Background - Several articles reported the existence of an association between ABO blood groups and COVID-19 susceptibility. Group A and group O individuals showed a higher and lower risk, respectively, of becoming infected. No association was observed between ABO groups and mortality. To verify this association, we performed a retrospective study of two cohorts of patients with different demographic and clinical characteristics. Material and methods - A total of 854 regular blood donors were recruited for convalescent plasma donation after recovering from a mild COVID-19 infection, and a group of 965 patients more severely affected who were transfused during hospitalisation were also included. We also investigated the potential role of the different risk factors on patient outcome and death. To eliminate the confounding effect of risk factors on mortality, a propensity score analysis was performed. Results - Blood group A and blood group O COVID-19 blood donors showed a higher and lower risk, respectively, for acquiring COVID-19. In contrast, this association was not found in the group of patients transfused during hospitalisation, probably due to the great differences in demographic and clinical characteristics between the two groups. Regarding severity, age was one of the most significant risk factors. ABO blood groups were also seen to represent important risk factors for COVID-19 severity and mortality. Mortality risk in group A individuals was significantly higher than in group O individuals (OR: 1.75, 95% CI: 1.22-2.51). Discussion - The association between the ABO blood groups and the susceptibility to acquire COVID-19 infection was confirmed in the group of blood donors. ABO blood groups were also associated to COVID-19 severity and mortality in the group of patients transfused during hospitalisation. Therefore, blood groups A and O are two important factors to be considered when evaluating the prognosis of patients with COVID-19. |
Note: | Reproducció del document publicat a: https://doi.org/10.2450/2020.0256-20 |
It is part of: | Blood Transfusion, 2020, vol. 19, num. 1, p. 54-63 |
URI: | http://hdl.handle.net/2445/194702 |
Related resource: | https://doi.org/10.2450/2020.0256-20 |
ISSN: | 1723-2007 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
704716.pdf | 666.51 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.