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http://hdl.handle.net/2445/194831
Title: | 3' untranslated regions: regulation at the end of the road |
Author: | El Mouali, Youssef Balsalobre Parra, Carlos |
Keywords: | Genètica molecular Bacteris RNA Molecular genetics Bacteria RNA |
Issue Date: | 2019 |
Publisher: | Springer Verlag |
Abstract: | Post-transcriptional gene regulation in bacteria plays a major role in the adaptation of bacterial cells to the changing conditions encountered in the environment. In bacteria, most of the regulation at the level of mRNA seems to be targeting the 5′untranslated regions where accessibility to the ribosome-binding site can be modulated to alter gene expression. In recent years, the role of 3′untranslated regions has gained attention also as a site for post-transcriptional regulation. In addition to be a source of trans-encoded small RNAs, the 3′untranslated regions can be targets to modulate gene expression. Taking recent findings in the post-transcriptional regulation of the hilD gene, encoding for the main regulator of virulence in Salmonella enterica serovar Typhimurium, we highlight the role of 3′untranslated regions as targets of post-transcriptional regulation mediated by small RNAs and discuss the implications of transcriptional elongation in the 3′UTR-mediated regulation in bacteria. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1007/s00294-018-0877-x |
It is part of: | Current Genetics, 2019, vol. 65, p. 127-131 |
URI: | http://hdl.handle.net/2445/194831 |
Related resource: | https://doi.org/10.1007/s00294-018-0877-x |
ISSN: | 0172-8083 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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