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Title: | Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments |
Author: | Vilaseca González, Isabel Avilés Jurado, Francesc Xavier Valduvieco, Izaskun Berenguer, Joan Grau, Juan José Baste, Neus Muxí Pradas, África Castillo, Paola Lehrer, Eduardo Jordana, Marta Ramírez Ruiz, Rosa Delia Costa, José Miguel Oleaga Zufiría, Laura Bernal Sprekelsen, Manuel |
Keywords: | Càncer de laringe Microcirurgia Làsers en cirurgia Cartílag Teixit connectiu Larynx cancer Microsurgery Lasers in surgery Cartilage Connective tissue |
Issue Date: | 27-Sep-2021 |
Publisher: | J. Wiley |
Abstract: | To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Background: To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Methods: Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease-specific survival (DSS), and laryngectomy-free survival (LFS) were evaluated. Results: The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR] = 0.289 [0.085-0.979]) and anterior (HR = 0.278 [0.128-0.605]) and posterior (HR = 0.269 [0.115-0.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR = 3.613 [1.537-8.495]) and posterior (HR = 5.195 [2.167-12.455]) PGS involvement were independent factors of total laryngectomy. Five-year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5-year LFS. Conclusions: Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/hed.26878 |
It is part of: | Head & Neck. Journal for the Sciences and Specialties of the Head and Neck, 2021, vol. 43, num. 12, p. 3832-3842 |
URI: | https://hdl.handle.net/2445/195211 |
Related resource: | https://doi.org/10.1002/hed.26878 |
ISSN: | 1043-3074 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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