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Title: Greater male than female variability in regional brain structure across the lifespan
Author: Wierenga, Lara M.
Doucet, Gaelle E.
Dima, Danai
Agartz, Ingrid
Aghajani, Moji
Akudjedu, Theophilus N.
Albajes Eizagirre, Anton
Alnaes, Dag
Alpert, Kathryn I.
Andreassen, Ole A.
Anticevic, Alan
Asherson, Philip
Banaschewski, Tobias
Bargalló Alabart, Núria​
Baumeister, Sarah
Baur Streubel, Ramona
Bertolino, Alessandro
Bonvino, Aurora
Boomsma, Dorret I.
Borgwardt, Stefan
Bourque, Josiane
den Braber, Anouk
Brandeis, Daniel
Breier, Alan
Brodaty, Henry
Brouwer, Rachel M.
Buitelaar, Jan K.
Busatto, Geraldo F.
Canales Rodríguez, Erick Jorge
Cannon, Dara M.
Caseras, Xavier
Castellanos, Francisco X.
Radua, Joaquim
Chaim-Avancini, Tiffany M.
Ching, Christopher R. K.
Lázaro García, Luisa
Martínez Zalacaín, Ignacio
Menchón Magriñá, José Manuel
Soriano Mas, Carles
Karolinska Schizophrenia Project (KaSP)
Keywords: Evolució del cervell
Anàlisi de variància
Diferències entre sexes
Evolution of the brain
Analysis of variance
Sex differences
Issue Date: 12-Oct-2020
Publisher: Wiley
Abstract: For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
Note: Reproducció del document publicat a:
It is part of: Human Brain Mapping, 2020, vol. 43, num. 1, p. 470-499
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ISSN: 1065-9471
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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