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http://hdl.handle.net/2445/197323
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DC Field | Value | Language |
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dc.contributor.author | Demontis, Dittie | - |
dc.contributor.author | Walters, G. Bragi | - |
dc.contributor.author | Athanasiadis, Georgios | - |
dc.contributor.author | Walters, Raymond | - |
dc.contributor.author | Therrien, Karen | - |
dc.contributor.author | Farajzadeh, Leila | - |
dc.contributor.author | Voloudakis, Georgios | - |
dc.contributor.author | Bendl, Jaroslav | - |
dc.contributor.author | Zeng, Biau | - |
dc.contributor.author | Zhang, Wen | - |
dc.contributor.author | Grove, Jakob | - |
dc.contributor.author | Als, Thomas D. | - |
dc.contributor.author | Duan, Jinjie | - |
dc.contributor.author | Satterstrom, F.Kyle | - |
dc.contributor.author | Bybjerg Grauholm, Jonas | - |
dc.contributor.author | Bækved Hansen, Marie | - |
dc.contributor.author | Gudmundsson, Ofaur O. | - |
dc.contributor.author | Magnusson, Sigurdur H. | - |
dc.contributor.author | Baldursson, Gisli | - |
dc.contributor.author | Davidsdottir, Katrin | - |
dc.contributor.author | Haraldsdottir, Gyda S. | - |
dc.contributor.author | Nielsen, Trine Tollerup | - |
dc.contributor.author | Agerbo, Esben | - |
dc.contributor.author | Hoffman, Gabriel E. | - |
dc.contributor.author | Dalsgaard, S. | - |
dc.contributor.author | Martin, Joanna | - |
dc.contributor.author | Ribasés Haro, Marta | - |
dc.contributor.author | Boomsma, Dorret I. | - |
dc.contributor.author | Soler Artigas, María | - |
dc.contributor.author | Roth Mota, Nina | - |
dc.contributor.author | Howrigan, Daniel | - |
dc.contributor.author | Medland, Sarah E. | - |
dc.contributor.author | Zayats, Tetyana | - |
dc.contributor.author | ADHD Working Group of the Psychiatric Genomics Consortium | - |
dc.contributor.author | iPSYCH-Broad Consortium | - |
dc.contributor.author | Nordentoft, Merete | - |
dc.contributor.author | Mors, Ole | - |
dc.contributor.author | Hougaard, David M. | - |
dc.contributor.author | Mortensen, Preben Bo | - |
dc.contributor.author | Cormand, Bru | - |
dc.date.accessioned | 2023-04-27T10:39:46Z | - |
dc.date.available | 2023-07-26T05:10:25Z | - |
dc.date.issued | 2023-01-26 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | http://hdl.handle.net/2445/197323 | - |
dc.description.abstract | Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development. Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. In exome-sequencing data from 17,896 individuals, we identified an increased load of rare protein-truncating variants in ADHD for a set of risk genes enriched with probable causal common variants, potentially implicating SORCS3 in ADHD by both common and rare variants. Bivariate Gaussian mixture modeling estimated that 84-98% of ADHD-influencing variants are shared with other psychiatric disorders. In addition, common-variant ADHD risk was associated with impaired complex cognition such as verbal reasoning and a range of executive functions, including attention. | - |
dc.format.extent | 18 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/s41588-022-01285-8 | - |
dc.relation.ispartof | Nature Genetics, 2023, vol. 55, p. 198-208 | - |
dc.relation.uri | https://doi.org/10.1038/s41588-022-01285-8 | - |
dc.rights | (c) Demontis, Dittie et al., 2023 | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Trastorns per dèficit d'atenció amb hiperactivitat en els adults | - |
dc.subject.classification | Genètica | - |
dc.subject.other | Attention deficit disorder with hyperactivity in adults | - |
dc.subject.other | Genetics | - |
dc.title | Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 724648 | - |
dc.date.updated | 2023-04-27T10:39:46Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
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724648.pdf | 1.1 MB | Adobe PDF | View/Open |
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