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https://hdl.handle.net/2445/198070| Title: | Impact of HIV kick-and-kill therapy on host epigenetic and transcriptional programs in PBMC, and viral rebound after cART interruption |
| Author: | Oriol-Tordera, Bruna Esteve-Codina, Anna Berdasco, María Gonçalves, Elena Esteller, Manel Hanke, Tomá Moltó, José Clotet, Bonaventura, 1953- Calle, María Luz Combadiere, Behazine Sànchez, Àlex (Sànchez Pla) Mothe, Beatriz Ruiz-Riol, Marta Brander, Christian |
| Keywords: | VIH (Virus) Epigenètica HIV (Viruses) Epigenetics |
| Issue Date: | 1-Jan-2021 |
| Publisher: | BioMed Central |
| Abstract: | Background: BCN02 was a pilot kick-and-kill clinical trial that combined therapeutic vaccination (MVA.HIVconsv) with the latency reversing agent romidepsin (RMD) followed by a monitored antiretroviral pause (MAP) in 15 early-treated HIV+ individuals (NCT02616874). Out of 12 evaluable participants for an omics subanalysis, 8 participants showed early (pVL > 2000 copies/mL < 4 weeks) and 4 a more delayed viral rebound (pVL > 2000 copies/mL > 4 weeks) in MAP. Systems biology analyses identified epigenetic and molecular mechanisms associated with response to vaccination and RMD and viral rebound kinetics. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1002/jia2.25659 |
| It is part of: | Journal of the International AIDS Society, 2021, vol. 24, num. S1, p. 36-38 |
| URI: | https://hdl.handle.net/2445/198070 |
| Related resource: | https://doi.org/10.1002/jia2.25659 |
| ISSN: | 1758-2652 |
| Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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