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Title: | Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder |
Author: | Hernández Rubio, Anna Sanvisens Bergé, Arantza Barbier Torres, Lucía Blanes, Rafael Miquel de Montagut, Laia Torrens, Marta Rubio, Gabriel Bolao, Ferran Zuluaga, Paola Fuster, Daniel Rodríguez de Fonseca, Fernando Farré Albaladejo, Magí Muga, Robert CohRTA Study Papasseit, Esther Pérez Mañá, Clara Poyatos, Lourdes García Marchena, Nuria Abellí, Enric Short, Antoni Moranta, Catalina Sion, Ana Ortega, Lluisa Bruguera, Pol Caballeria, Elsa Messeguer, Ana Fonseca, Francina Mestre Pinto, Juan Ignacio Alías, María Dinamarca, Fernando Pavón Morón, Francisco Javier Araos, Pedro Flores López, María Serrano, Antonia Marcos, Miguel Martín González, M. Candelaria Pérez Hernández, Onán Manzanares, Jorge Illescas, Lucía |
Keywords: | Alcoholisme Dèficit de magnesi Alcoholism Magnesium deficiency diseases |
Issue Date: | 1-Apr-2023 |
Publisher: | Elsevier |
Abstract: | Introduction: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.Patients and Methods: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.Results: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimen-tation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 >= 3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3-23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0-26.2) were the only factors associated with hypoMg.Conclusions: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.drugalcdep.2023.109822 |
It is part of: | Drug and Alcohol Dependence, 2023, vol. 245 |
URI: | http://hdl.handle.net/2445/198665 |
Related resource: | https://doi.org/10.1016/j.drugalcdep.2023.109822 |
ISSN: | 1879-0046 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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