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http://hdl.handle.net/2445/199606
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DC Field | Value | Language |
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dc.contributor.author | Betancor, Diana | - |
dc.contributor.author | Olaguibel, José María | - |
dc.contributor.author | Rodrigo Muñoz, José Manuel | - |
dc.contributor.author | Arismendi, Ebymar | - |
dc.contributor.author | Barranco, Pilar | - |
dc.contributor.author | Barroso, Blanca | - |
dc.contributor.author | Bobolea, Irina | - |
dc.contributor.author | Cárdaba, Blanca | - |
dc.contributor.author | Cruz, María Jesús | - |
dc.contributor.author | Curto, Elena | - |
dc.contributor.author | Pozo, Victoria del | - |
dc.contributor.author | González Barcala, Francisco Javier | - |
dc.contributor.author | Martínez Rivera, Carlos | - |
dc.contributor.author | Mullol i Miret, Joaquim | - |
dc.contributor.author | Muñoz, Xavier | - |
dc.contributor.author | Picado Vallés, César | - |
dc.contributor.author | Plaza, Vicente | - |
dc.contributor.author | Quirce, Santiago | - |
dc.contributor.author | Rial Prado, Manuel Jorge | - |
dc.contributor.author | Soto, Lorena | - |
dc.contributor.author | Valero, Antonio | - |
dc.contributor.author | Valverde Monge, Marcela | - |
dc.contributor.author | Sastre, Joaquín | - |
dc.date.accessioned | 2023-06-21T11:54:02Z | - |
dc.date.available | 2023-06-21T11:54:02Z | - |
dc.date.issued | 2022-08-20 | - |
dc.identifier.issn | 2045-7022 | - |
dc.identifier.uri | http://hdl.handle.net/2445/199606 | - |
dc.description.abstract | Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non-invasive biomarkers has been investigated to its pathobiology. Heany et al proposed a clinical algorithm that classifies severe asthmatic patients into likely-eosinophilic phenotypes, based on accessible biomarkers: PBE, current treatment, FeNO, presence of nasal polyps (NP) and age of onset.We assessed the concordance between the algorithm proposed by Heany et al. with sputum examination, the gold standard, in 145 asthmatic patients of the MEGA cohort with varying grades of severity.No correlation was found between both classifications 0.025 (CI = 0.013-0.037). Moreover, no relationship was found between sputum eosinophilia and peripheral blood eosinophilia count in the total studied population.In conclusion, our results suggest that grouping the biomarkers proposed by Heany et al. are insufficient to diagnose eosinophilic phenotypes in asthmatic patients. Sputum analysis remains the gold standard to assess airway inflammation.© 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/clt2.12182 | - |
dc.relation.ispartof | Clinical And Translational Allergy, 2022, vol. 12, num. 8 | - |
dc.relation.uri | https://doi.org/10.1002/clt2.12182 | - |
dc.rights | cc by (c) Betancor, Diana et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Asma | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Matemàtica aplicada | - |
dc.subject.other | Asthma | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Applied mathematics | - |
dc.title | How reliably can algorithms identify eosinophilic asthma phenotypes using non-invasive biomarkers? | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-06-20T10:45:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9329094 | - |
dc.identifier.pmid | 36000018 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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How reliably can algorithms identify eosinophilic asthma phenotypes using_ClinTranslAllergy.pdf | 216.71 kB | Adobe PDF | View/Open |
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