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Title: | How reliably can algorithms identify eosinophilic asthma phenotypes using non-invasive biomarkers? |
Author: | Betancor, Diana Olaguibel, José María Rodrigo Muñoz, José Manuel Arismendi, Ebymar Barranco, Pilar Barroso, Blanca Bobolea, Irina Cárdaba, Blanca Cruz, María Jesús Curto, Elena Pozo, Victoria del González Barcala, Francisco Javier Martínez Rivera, Carlos Mullol i Miret, Joaquim Muñoz, Xavier Picado Vallés, César Plaza, Vicente Quirce, Santiago Rial Prado, Manuel Jorge Soto, Lorena Valero, Antonio Valverde Monge, Marcela Sastre, Joaquín |
Keywords: | Asma Marcadors bioquímics Matemàtica aplicada Asthma Biochemical markers Applied mathematics |
Issue Date: | 20-Aug-2022 |
Publisher: | Wiley |
Abstract: | Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non-invasive biomarkers has been investigated to its pathobiology. Heany et al proposed a clinical algorithm that classifies severe asthmatic patients into likely-eosinophilic phenotypes, based on accessible biomarkers: PBE, current treatment, FeNO, presence of nasal polyps (NP) and age of onset.We assessed the concordance between the algorithm proposed by Heany et al. with sputum examination, the gold standard, in 145 asthmatic patients of the MEGA cohort with varying grades of severity.No correlation was found between both classifications 0.025 (CI = 0.013-0.037). Moreover, no relationship was found between sputum eosinophilia and peripheral blood eosinophilia count in the total studied population.In conclusion, our results suggest that grouping the biomarkers proposed by Heany et al. are insufficient to diagnose eosinophilic phenotypes in asthmatic patients. Sputum analysis remains the gold standard to assess airway inflammation.© 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/clt2.12182 |
It is part of: | Clinical And Translational Allergy, 2022, vol. 12, num. 8 |
URI: | http://hdl.handle.net/2445/199606 |
Related resource: | https://doi.org/10.1002/clt2.12182 |
ISSN: | 2045-7022 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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