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http://hdl.handle.net/2445/201468
Title: | Risk Prescriptions of Strong Opioids in the Treatment of Chronic Non-Cancer Pain by Primary Care Physicians in Catalonia: Opicat Padris Project |
Author: | Perelló Bratescu, Aina Dürsteler, Christian Álvarez- Carrera, Maria Asunción Granés, Laura Kostov, Belchin Sisó Almirall, Antoni |
Keywords: | Tractament del dolor Avaluació del risc per la salut Opiacis Pain treatment Health risk assessment Opioids |
Issue Date: | 31-Jan-2022 |
Publisher: | MDPI |
Abstract: | The prescription of strong opioids (SO) for chronic non-cancer pain (CNCP) is steadily increasing. This entails a high risk of adverse effects, a risk that increases with the concomitant prescription of SO with central nervous system depressant drugs and with the use of SO for non-recommended indications. In order to examine this concomitant risk prescription, we designed a descriptive, longitudinal, retrospective population-based study. Patients aged >= 15 years with a continued SO prescription for >= 3 months during 2013-2017 for CNCP were included. Of these, patients who had received concomitant prescriptions of SO and risk drugs (gabapentinoids, benzodiazepines and antidepressants) and those who had received immediate-release fentanyl (IRF) were selected. The study included 22,691 patients; 20,354 (89.7%) patients received concomitant risk prescriptions. Men and subjects with a higher socioeconomic status received fewer concomitant risk prescriptions. Benzodiazepines or Z-drugs were prescribed concomitantly with SO in 15,883 (70%) patients, antidepressants in 14,932 (65%) and gabapentinoids in 11,267 (49%), while 483 (21.32%) patients received IRF (2266 prescriptions in total) without a baseline SO. In conclusion, our study shows that a high percentage of patients prescribed SO for CNCP received concomitant prescriptions with known risks, as well as IRF for unauthorized indications. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijerph19031652 |
It is part of: | International Journal Of Environmental Research And Public Health, 2022, vol. 19, num. 3, p. 1652 |
URI: | http://hdl.handle.net/2445/201468 |
Related resource: | https://doi.org/10.3390/ijerph19031652 |
ISSN: | 1660-4601 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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Risk Prescriptions of Strong Opioids in the Treatment of Chronic Non-Cancer Pain by Primary Care Physicians_EnvironmentalResearch.pdf | 889.4 kB | Adobe PDF | View/Open |
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