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http://hdl.handle.net/2445/206164
Title: | An extended kinetic model-based correction factor equation to account hemodialysis post-treatment hemoconcentration |
Author: | Gomez, Miquel Arias Guillén, Marta Maduell Canals, Francesc |
Keywords: | Hemodiàlisi Cinética química Hemodialysis Chemical kinetics |
Issue Date: | 18-Mar-2023 |
Abstract: | The hemoconcentration effect for middle weight solutes in hemodialysis is corrected by oversimplified methods based on hematocrit changes or distribution volume variations. Here we implemented a variable volume dual pool kinetic model targeted at obtaining a precise correction factor equation for extracellularly distributed solutes based on relevant kinetic parameters such as the ultrafiltration to dry weight ratio UF/DW, the dialyzer clearance, Kd, the intercompartment mass-transfer coefficient, Kc, and the central compartment to extracellular volume ratio, α. More than 300,000 solutions of the model were computed, performing a sweep among physiological values of the proposed kinetic parameters, resulting in a linear regression denoted by the expression fcorr = 1.0707 - 5.2246 (UF/DW) - 0.0005 Kd - 0.0004 Kc - 0.0007 α, with an excellent coefficient of determination R2 = 0.983. The presented fcorr provides a substantial extension of the currently implemented methods to estimate the hemoconcentration factor for middle and high molecular weight extracellular distributed solutes in hemodialysis. |
Note: | Reproducció del document publicat a: https://doi.org/10.1177/03913988231160803 |
It is part of: | International Journal Of Artificial Organs, 2023, vol. 46, num. 5, p. 314-317 |
URI: | http://hdl.handle.net/2445/206164 |
Related resource: | https://doi.org/10.1177/03913988231160803 |
ISSN: | 1724-6040 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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