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http://hdl.handle.net/2445/206169
Title: | Correlated motions in DNA. Beyond base-pair step models of DNA flexibility |
Author: | López-Güell, Kim Battistini, Federica Orozco López, Modesto |
Keywords: | ADN Biologia computacional DNA Computational biology |
Issue Date: | 11-Apr-2023 |
Publisher: | Oxford University Press |
Abstract: | Traditional mesoscopic models of DNA flexibility use a reductionist-local approach, which assumes that the flexibility of DNA can be expressed as local harmonic movements (at the base-pair step level) in the helical space, ignoring multimodality and correlations in DNA movements, which have in reality a large impact in modulating DNA movements. We present a new multimodal-harmonic correlated model, which takes both contributions into account, providing, with a small computational cost, results of an unprecedented local and global quality. The accuracy of this method and its computational efficiency make it an alternative to explore the dynamics of long segments of DNA, approaching the chromatin range. |
Note: | Reproducció del document publicat a: https://doi.org/10.1093/nar/gkad136 |
It is part of: | Nucleic Acids Research, 2023, vol. 51, num.6, p. 2633-2640 |
URI: | http://hdl.handle.net/2445/206169 |
Related resource: | https://doi.org/10.1093/nar/gkad136 |
ISSN: | 0305-1048 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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File | Description | Size | Format | |
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261012.pdf | 3.06 MB | Adobe PDF | View/Open |
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