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http://hdl.handle.net/2445/206270
Title: | Real-life epidemiology and current outcomes of hospitalized adults with invasive fungal infections |
Author: | Monzo Gallo, Patricia Chumbita, Mariana Lopera, Carlos Aiello, Tommaso F. Peyrony, Oliver Bodro, Marta Herrera, Sabina Sempere, Abiu Fernández Pittol, Mariana Cuesta, Genoveva Simó, Sílvia Benegas, Mariana Fortuny, Clàudia Mensa, Josep Soriano, Àlex Puerta Alcalde, Pedro Marco, Francesc Garcia Vidal, Carolina FUNGIclinic group |
Keywords: | Aspergil·losi Pneumònia Aspergillosis Pneumonia |
Issue Date: | 1-Mar-2023 |
Publisher: | Oxford University Press |
Abstract: | We aimed to describe the current epidemiology of both hosts with invasive fungal infections (IFI) and causative fungi. And detail outcomes of these infections at 12 weeks in a real-life cohort of hospitalized patients. The study was retrospective and observational to describe IFI diagnosed in a tertiary hospital (February 2017 - December 2021). We included all consecutive patients meeting criteria for proven or probable IFI according to EORTC-MSG and other criteria. A total of 367 IFI were diagnosed. 11.7% were breakthrough infections, and 56.4% were diagnosed in the intensive care unit (ICU). Corticosteroid use (41.4%) and prior viral infection (31.3%) were the most common risk factors for IFI. Lymphoma and pneumocystis pneumonia were the most common baseline and fungal diseases. Only 12% of IFI occurred in patients with neutropenia. Fungal cultures were the most important diagnostic tests (85.8%). The most frequent IFI were candidemia (42.2%) and invasive aspergillosis (26.7%). Azole-resistant candida strains and non-fumigatus aspergillus infection represented 36.1% and 44.5% of the cases, respectively. Pneumocystosis (16.9%), cryptococcosis (4.6%) and mucormycosis (2.7%) were also frequent, as well as mixed infections (3.4%). Rare fungi accounted for 9.5% of infections. Overall IFI mortality at 12 weeks was 32.2%; higher rates were observed for Mucorales (55.6%), Fusarium (50%) and mixed infections (60%). We documented emerging changes in both hosts and real-life IFI epidemiology. Physicians should be aware of these changes to suspect infections and be aggressive in diagnoses and treatments. Currently, outcomes for such clinical scenarios remain extremely poor.© The Author(s) 2023. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1093/mmy/myad021 |
It is part of: | Medical Mycology, 2023, vol. 61, num. 3 |
URI: | http://hdl.handle.net/2445/206270 |
Related resource: | https://doi.org/10.1093/mmy/myad021 |
ISSN: | 1460-2709 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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edited_IFI_VF rev MM_main document.pdf | 284.22 kB | Adobe PDF | View/Open |
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