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DC Field | Value | Language |
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dc.contributor.author | Bastard, Paul | - |
dc.contributor.author | Gervais, Adrian | - |
dc.contributor.author | Taniguchi, Maki | - |
dc.contributor.author | Saare, Liisa | - |
dc.contributor.author | Särekannu, Karita | - |
dc.contributor.author | Le Voyer, Tom | - |
dc.contributor.author | Philippot, Quentin | - |
dc.contributor.author | Rosain, Jérémie | - |
dc.contributor.author | Bizien, Lucy | - |
dc.contributor.author | Asano, Takaki | - |
dc.contributor.author | Garcia Prat, Marina | - |
dc.contributor.author | Erdeniz, Emine Hafize | - |
dc.contributor.author | Álvarez Escudero, Julián | - |
dc.contributor.author | Amara, Ali | - |
dc.contributor.author | Dalgard, Clifton L. | - |
dc.contributor.author | Gómez Rial, José | - |
dc.contributor.author | Taboada Muñiz, Manuel | - |
dc.contributor.author | Antela López, Antonio | - |
dc.contributor.author | Barbeito Castiñeiras, Gema | - |
dc.contributor.author | Bello Paderne, Xabier | - |
dc.contributor.author | Mironska, Kristina | - |
dc.contributor.author | Zawadzki, Pawel | - |
dc.contributor.author | Belot, Alexandre | - |
dc.contributor.author | Ben García, Miriam | - |
dc.contributor.author | Carral García, María Victoria | - |
dc.contributor.author | Soumelis, Vassili | - |
dc.contributor.author | Cebey López, Miriam | - |
dc.contributor.author | Coira Nieto, Amparo | - |
dc.contributor.author | Ozcelik, Tayfun | - |
dc.contributor.author | Trastoy Pena, Rocío | - |
dc.contributor.author | Desai, Murkesh | - |
dc.contributor.author | Halwani, Rabih | - |
dc.contributor.author | Soler Palacin, Pere | - |
dc.contributor.author | Schidlowski, Laire | - |
dc.contributor.author | Conde Pájaro, Mónica | - |
dc.contributor.author | Pischedda, Sara | - |
dc.contributor.author | Zhang, Qian | - |
dc.contributor.author | Gulhan, Belgin | - |
dc.contributor.author | Gómez Carballa, Alberto | - |
dc.contributor.author | Casanova, Jean Laurent | - |
dc.contributor.author | Portela Romero, Manuel | - |
dc.contributor.author | Migaud, Mélanie | - |
dc.contributor.author | Wauters, Joost | - |
dc.contributor.author | Karbuz, Adem | - |
dc.contributor.author | Pose Reino, Antonio | - |
dc.contributor.author | Navarro De La Cruz, Daniel | - |
dc.contributor.author | Prada Hervella, Gloria María | - |
dc.contributor.author | Drolet, Beth A. | - |
dc.contributor.author | Husain, Maya | - |
dc.contributor.author | Queiro Verdes, Teresa | - |
dc.contributor.author | Redondo Collazo, Lorenzo | - |
dc.contributor.author | Anderson, Mark S. | - |
dc.contributor.author | Martinón Torres, Federico | - |
dc.contributor.author | Spaan, András N. | - |
dc.contributor.author | Fernández Pérez, Cristina | - |
dc.contributor.author | Regueiro Casuso, Patricia | - |
dc.contributor.author | El Baghdadi, Jamila | - |
dc.contributor.author | Peterson, Pärt | - |
dc.contributor.author | Conti, Francesca | - |
dc.contributor.author | Rey García, Susana | - |
dc.contributor.author | Hammarström, Lennart | - |
dc.contributor.author | Rey Vázquez, Sara | - |
dc.contributor.author | Cyrus, Cyril | - |
dc.contributor.author | Riveiro Blanco, Vanessa | - |
dc.contributor.author | Rivero Calle, Irene | - |
dc.contributor.author | Parra Martínez, Alba | - |
dc.contributor.author | Rivero Velasco, Carmen | - |
dc.contributor.author | Tsumura, Miyuki | - |
dc.contributor.author | Su, Helen C. | - |
dc.contributor.author | Mogensen, Trine H. | - |
dc.contributor.author | Pérez de Diego, Rebeca | - |
dc.contributor.author | Von Bernuth, Horst | - |
dc.contributor.author | Andreakos, Evangelos | - |
dc.contributor.author | Tipu, Imran | - |
dc.contributor.author | Domínguez Santalla, María Jesús | - |
dc.contributor.author | Treviño Castellano, Mercedes | - |
dc.contributor.author | Cheikh, Nathalie | - |
dc.contributor.author | Arias, Andrés A. | - |
dc.contributor.author | Alkhater, Suzan A. | - |
dc.contributor.author | Martinón Torres, Federico | - |
dc.contributor.author | Arkin, Lisa M. | - |
dc.contributor.author | Morio, Tomohiro | - |
dc.contributor.author | Kanik Yuksek, Saliha | - |
dc.contributor.author | Baris Feldman, Hagit | - |
dc.contributor.author | Bastard, Paul | - |
dc.contributor.author | Tanaka, Junko | - |
dc.contributor.author | Pérez Del Molino Bernal, Marisa | - |
dc.contributor.author | Colobran, Roger | - |
dc.contributor.author | Belot, Alexandre | - |
dc.contributor.author | Castagnoli, Riccardo | - |
dc.contributor.author | Biggs, Catherine M. | - |
dc.contributor.author | Perez Tur, Jordi | - |
dc.contributor.author | Rivière, Jacques G. | - |
dc.contributor.author | Currás Tuala, María José | - |
dc.contributor.author | Bogunovic, Dusan | - |
dc.contributor.author | Bolze, Alexandre | - |
dc.contributor.author | Imai, Kohsuke | - |
dc.contributor.author | Alkan, Gulsum | - |
dc.contributor.author | Tillmann, Vallo | - |
dc.contributor.author | Gómez Carballa, Alberto | - |
dc.contributor.author | Abel, Laurent | - |
dc.contributor.author | Bondarenko, Anastasiia | - |
dc.contributor.author | Pesole, Graziano | - |
dc.contributor.author | Escoda, Simon | - |
dc.contributor.author | Espinosa Padilla, Sara | - |
dc.contributor.author | Ng, Lisa F.P. | - |
dc.contributor.author | Bousfiha, Ahmed A. | - |
dc.contributor.author | Brodin, Petter | - |
dc.contributor.author | Bryceson, Yenan | - |
dc.contributor.author | Neven, Bénédicte | - |
dc.contributor.author | Lence Massa, Beatriz | - |
dc.contributor.author | Butte, Manish J. | - |
dc.contributor.author | Casanova, Jean-laurent | - |
dc.contributor.author | Meyts, Isabelle | - |
dc.contributor.author | Casari, Giorgio | - |
dc.contributor.author | Christodoulou, John | - |
dc.contributor.author | González Granado, Luis Ignacio | - |
dc.contributor.author | Notarangelo, Luigi D. | - |
dc.contributor.author | Tangye, Stuart G. | - |
dc.contributor.author | Zhang, Qian | - |
dc.contributor.author | Saito Villanueva, Carla | - |
dc.contributor.author | Morio, Tomohiro | - |
dc.contributor.author | Jarvis, Erich D. | - |
dc.contributor.author | Costa Alcalde, José Javier | - |
dc.contributor.author | Calviño Suárez, Cristina | - |
dc.contributor.author | Eloy, Philippine | - |
dc.contributor.author | García Allut, José Luis | - |
dc.contributor.author | Jouanguy, Emmanuelle | - |
dc.contributor.author | González Barcala, Francisco Javier | - |
dc.contributor.author | Emiroglu, Melike | - |
dc.contributor.author | Haerynck, Filomeen | - |
dc.contributor.author | Hagin, David | - |
dc.contributor.author | Kaja, Elżbieta | - |
dc.contributor.author | Abou Tayoun, Ahmad | - |
dc.contributor.author | Pazo Núñez, María | - |
dc.contributor.author | Karamitros, Timokratis | - |
dc.contributor.author | Kisand, Kai | - |
dc.contributor.author | Planas, Anna M. | - |
dc.contributor.author | Piñeiro Rodríguez, Lidia | - |
dc.contributor.author | Roussel, Lucie | - |
dc.contributor.author | Ku, Cheng Lung | - |
dc.contributor.author | Thorball, Christian | - |
dc.contributor.author | Jabandziev, Petr | - |
dc.contributor.author | Leboráns Iglesias, Pilar | - |
dc.contributor.author | Lau, Yu Lung | - |
dc.contributor.author | Zhang, Shen Ying | - |
dc.contributor.author | Ling, Yun | - |
dc.contributor.author | Viz Lasheras, Sandra | - |
dc.contributor.author | Lucas, Carrie L. | - |
dc.contributor.author | Mansouri, Davood | - |
dc.contributor.author | Maródi, László | - |
dc.contributor.author | Guerra Liñares, Beatriz | - |
dc.contributor.author | Ostrowski, Sisse Rye | - |
dc.contributor.author | Trouillet Assant, Sophie | - |
dc.contributor.author | Puel, Anne | - |
dc.contributor.author | Elmas Bozdemir, Sefika | - |
dc.contributor.author | Keles, Sevgi | - |
dc.contributor.author | Rodríguez Núñez, Nuria | - |
dc.contributor.author | Cooper, Megan A. | - |
dc.contributor.author | Novelli, Antonio | - |
dc.contributor.author | Prando, Carolina | - |
dc.contributor.author | Valdés Cuadrado, Luis | - |
dc.contributor.author | Haerynck, Filomeen | - |
dc.contributor.author | Pujol, Aurora | - |
dc.contributor.author | Brodin, Petter | - |
dc.contributor.author | Al Mulla, Fahd | - |
dc.contributor.author | Puel, Anne | - |
dc.contributor.author | Quintana Murci, Lluis | - |
dc.contributor.author | López Lago, Ana | - |
dc.contributor.author | Husebye, Eystein | - |
dc.contributor.author | Ramaswamy, Sathishkumar | - |
dc.contributor.author | Vilas Iglesias, María Soledad | - |
dc.contributor.author | Renia, Laurent | - |
dc.contributor.author | Cobat, Aurélie | - |
dc.contributor.author | Lendoiro Fuentes, Marta | - |
dc.contributor.author | Colobran, Roger | - |
dc.contributor.author | Resnick, Igor | - |
dc.contributor.author | Rodríguez Gallego, Carlos | - |
dc.contributor.author | Pan Hammarström, Qiang | - |
dc.contributor.author | Varela García, Pablo | - |
dc.contributor.author | Dacosta Urbieta, Ana Isabel | - |
dc.contributor.author | Pape, Jean W. | - |
dc.contributor.author | Sancho Shimizu, Vanessa | - |
dc.contributor.author | Abi Haidar, Anthony | - |
dc.contributor.author | Pardo Seco, Jacobo | - |
dc.contributor.author | Trouillet Assant, Sophie | - |
dc.contributor.author | Abel, Laurent | - |
dc.contributor.author | Sediva, Anna | - |
dc.contributor.author | Tandjaoui Lambiotte, Yacine | - |
dc.contributor.author | Seppänen, Mikko R.J. | - |
dc.contributor.author | Froidure, Antoine | - |
dc.contributor.author | Shahrooei, Mohammed | - |
dc.contributor.author | Shcherbina, Anna | - |
dc.contributor.author | Rodríguez Tenreiro Sánchez, Carmen | - |
dc.contributor.author | Slaby, Ondrej | - |
dc.contributor.author | Snow, Andrew L. | - |
dc.contributor.author | Díaz Esteban, Blanca | - |
dc.contributor.author | Jouanguy, Emmanuelle | - |
dc.contributor.author | Prando, Carolina | - |
dc.contributor.author | Hatipoglu, Nevin | - |
dc.contributor.author | López Franco, Montserrat | - |
dc.contributor.author | Vinh, Donald C. | - |
dc.contributor.author | Cobat, Aurélie | - |
dc.contributor.author | Pan-hammarström, Qiang | - |
dc.contributor.author | Tiberghien, Pierre | - |
dc.contributor.author | Duval, Xavier | - |
dc.contributor.author | Boisson, Bertrand | - |
dc.contributor.author | Fellay, Jacques | - |
dc.contributor.author | Bastón Rey, Iria | - |
dc.contributor.author | Salas, Antonio | - |
dc.contributor.author | Béziat, Vivien | - |
dc.contributor.author | Condino Neto, Antonio | - |
dc.contributor.author | Hsieh, Elena W.y. | - |
dc.contributor.author | Borghesi, Alessandro | - |
dc.contributor.author | Pession, Andrea | - |
dc.contributor.author | Covid Clinicians | - |
dc.contributor.author | Itan, Yuval | - |
dc.contributor.author | Saborido Paz, Eva | - |
dc.contributor.author | Andreakos, Evangelos | - |
dc.contributor.author | Bousfiha, Ahmed A. | - |
dc.contributor.author | Franco, José Luis | - |
dc.contributor.author | Marr, Nico | - |
dc.contributor.author | Bayhan, Gülsün Iclal | - |
dc.contributor.author | Mentis, Alexios Fotios A. | - |
dc.contributor.author | Okada, Satoshi | - |
dc.contributor.author | Hammarström, Lennart | - |
dc.contributor.author | Mogensen, Trine H. | - |
dc.contributor.author | Rodríguez Gallego, Carlos | - |
dc.contributor.author | Flores, Carlos | - |
dc.contributor.author | Sadiki Orayyou, José Miguel | - |
dc.contributor.author | Fernández Villaverde, Juan | - |
dc.contributor.author | Ferreiro Iglesias, Rocio | - |
dc.contributor.author | Núñez Masid, Eloína | - |
dc.contributor.author | Mentré, France | - |
dc.contributor.author | Tancevski, Ivan | - |
dc.contributor.author | Ahlijah, Gloria | - |
dc.contributor.author | Gen Covid Study Group | - |
dc.contributor.author | Novelli, Giuseppe | - |
dc.contributor.author | Zatz, Mayana | - |
dc.contributor.author | Covid Human Genetic Effort | - |
dc.contributor.author | Perlin, David S. | - |
dc.contributor.author | Soudee, Camille | - |
dc.contributor.author | Arseguel, Vincent | - |
dc.contributor.author | Grimbacher, Bodo | - |
dc.contributor.author | Lévy, Romain | - |
dc.contributor.author | Abolhassani, Hassan | - |
dc.contributor.author | Ozcelik, Tayfun | - |
dc.contributor.author | Sahanic, Sabina | - |
dc.contributor.author | Galbán Rodríguez, Cristóbal | - |
dc.contributor.author | Gorochov, Guy | - |
dc.contributor.author | Tancevski, Ivan | - |
dc.contributor.author | Nukui, Yoko | - |
dc.contributor.author | Tüter Öz, Şadiye Kübra | - |
dc.contributor.author | O’farrelly, Cliona | - |
dc.contributor.author | Condino Neto, Antonio | - |
dc.contributor.author | Okada, Satoshi | - |
dc.contributor.author | Hayakawa, Seiichi | - |
dc.contributor.author | García Vicente, Luisa | - |
dc.contributor.author | Heath, James R. | - |
dc.contributor.author | Aguilera Albesa, Sergio | - |
dc.contributor.author | Chrousos, George P. | - |
dc.contributor.author | Ortolá Devesa, Juan Bautista | - |
dc.contributor.author | Michos, Athanasios | - |
dc.contributor.author | Beek, Diederik Van De | - |
dc.contributor.author | Tatsi, Elizabeth Barbara | - |
dc.contributor.author | Filippatos, Filippos | - |
dc.contributor.author | Duvlis, Sotirija | - |
dc.contributor.author | Rodriguez Palmero, Agusti | - |
dc.contributor.author | Troya, Jesus | - |
dc.contributor.author | Constantinescu, Stefan N. | - |
dc.contributor.author | Serén Fernández, Sonia | - |
dc.contributor.author | Aiuti, Alessandro | - |
dc.contributor.author | Gregersen, Peter K. | - |
dc.contributor.author | Marseglia, Gian Luigi | - |
dc.contributor.author | Soler Palacín, Pere | - |
dc.contributor.author | Kisand, Kai | - |
dc.contributor.author | El Bakkouri, Jalila | - |
dc.contributor.author | Temel, Şehime Gülsün | - |
dc.contributor.author | Metin Akcan, Ozge | - |
dc.contributor.author | Turvey, Stuart E. | - |
dc.contributor.author | Javouhey, Etienne | - |
dc.contributor.author | Kılıç, Ahmet Osman | - |
dc.contributor.author | Souto Sanmartín, Pablo | - |
dc.contributor.author | Pujol, Aurora | - |
dc.contributor.author | Ozkaya Parlakay, Aslinur | - |
dc.contributor.author | Papadaki, Maria | - |
dc.contributor.author | Giráldez Vázquez, Elena | - |
dc.contributor.author | Quartier, Pierre | - |
dc.contributor.author | Meyts, Isabelle | - |
dc.contributor.author | Slaba, Katerina | - |
dc.contributor.author | Uddin, Mohammed J. | - |
dc.contributor.author | Sevketoglu, Esra | - |
dc.contributor.author | Al Muhsen, Saleh | - |
dc.contributor.author | Valencia Ramos, Juan | - |
dc.contributor.author | Salas, Antonio | - |
dc.contributor.author | Yahşi, Aysun | - |
dc.contributor.author | Aguilera Guirao, Antonio | - |
dc.contributor.author | Pérez Freixo, Hugo | - |
dc.contributor.author | Furkan Uddin, K.M. | - |
dc.contributor.author | Milner, Joshua D. | - |
dc.contributor.author | Okamoto, Keisuke | - |
dc.date.accessioned | 2024-02-16T17:00:45Z | - |
dc.date.available | 2024-02-16T17:00:45Z | - |
dc.date.issued | 2024-01-04 | - |
dc.identifier.issn | 1540-9538 | - |
dc.identifier.uri | http://hdl.handle.net/2445/207702 | - |
dc.description.abstract | We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2. | - |
dc.format.extent | 45 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Rockefeller University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1084/jem.20231353 | - |
dc.relation.ispartof | Journal of Experimental Medicine, 2024, vol. 221, num. 2 | - |
dc.relation.uri | https://doi.org/10.1084/jem.20231353 | - |
dc.rights | cc by (c) Bastard, Paul et al., 2024 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Autoanticossos | - |
dc.subject.classification | COVID-19 | - |
dc.subject.other | Autoantibodies | - |
dc.subject.other | COVID-19 | - |
dc.title | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2024-02-16T15:11:53Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 38175961 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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