Title: | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
Author: | Bastard, Paul Gervais, Adrian Taniguchi, Maki Saare, Liisa Särekannu, Karita Le Voyer, Tom Philippot, Quentin Rosain, Jérémie Bizien, Lucy Asano, Takaki Garcia Prat, Marina Erdeniz, Emine Hafize Álvarez Escudero, Julián Amara, Ali Dalgard, Clifton L. Gómez Rial, José Taboada Muñiz, Manuel Antela López, Antonio Barbeito Castiñeiras, Gema Bello Paderne, Xabier Mironska, Kristina Zawadzki, Pawel Belot, Alexandre Ben García, Miriam Carral García, María Victoria Soumelis, Vassili Cebey López, Miriam Coira Nieto, Amparo Ozcelik, Tayfun Trastoy Pena, Rocío Desai, Murkesh Halwani, Rabih Soler Palacin, Pere Schidlowski, Laire Conde Pájaro, Mónica Pischedda, Sara Zhang, Qian Gulhan, Belgin Gómez Carballa, Alberto Casanova, Jean Laurent Portela Romero, Manuel Migaud, Mélanie Wauters, Joost Karbuz, Adem Pose Reino, Antonio Navarro De La Cruz, Daniel Prada Hervella, Gloria María Drolet, Beth A. Husain, Maya Queiro Verdes, Teresa Redondo Collazo, Lorenzo Anderson, Mark S. Martinón Torres, Federico Spaan, András N. Fernández Pérez, Cristina Regueiro Casuso, Patricia El Baghdadi, Jamila Peterson, Pärt Conti, Francesca Rey García, Susana Hammarström, Lennart Rey Vázquez, Sara Cyrus, Cyril Riveiro Blanco, Vanessa Rivero Calle, Irene Parra Martínez, Alba Rivero Velasco, Carmen Tsumura, Miyuki Su, Helen C. Mogensen, Trine H. Pérez de Diego, Rebeca Von Bernuth, Horst Andreakos, Evangelos Tipu, Imran Domínguez Santalla, María Jesús Treviño Castellano, Mercedes Cheikh, Nathalie Arias, Andrés A. Alkhater, Suzan A. Martinón Torres, Federico Arkin, Lisa M. Morio, Tomohiro Kanik Yuksek, Saliha Baris Feldman, Hagit Bastard, Paul Tanaka, Junko Pérez Del Molino Bernal, Marisa Colobran, Roger Belot, Alexandre Castagnoli, Riccardo Biggs, Catherine M. Perez Tur, Jordi Rivière, Jacques G. Currás Tuala, María José Bogunovic, Dusan Bolze, Alexandre Imai, Kohsuke Alkan, Gulsum Tillmann, Vallo Gómez Carballa, Alberto Abel, Laurent Bondarenko, Anastasiia Pesole, Graziano Escoda, Simon Espinosa Padilla, Sara Ng, Lisa F.P. Bousfiha, Ahmed A. Brodin, Petter Bryceson, Yenan Neven, Bénédicte Lence Massa, Beatriz Butte, Manish J. Casanova, Jean-laurent Meyts, Isabelle Casari, Giorgio Christodoulou, John González Granado, Luis Ignacio Notarangelo, Luigi D. Tangye, Stuart G. Zhang, Qian Saito Villanueva, Carla Morio, Tomohiro Jarvis, Erich D. Costa Alcalde, José Javier Calviño Suárez, Cristina Eloy, Philippine García Allut, José Luis Jouanguy, Emmanuelle González Barcala, Francisco Javier Emiroglu, Melike Haerynck, Filomeen Hagin, David Kaja, Elżbieta Abou Tayoun, Ahmad Pazo Núñez, María Karamitros, Timokratis Kisand, Kai Planas, Anna M. Piñeiro Rodríguez, Lidia Roussel, Lucie Ku, Cheng Lung Thorball, Christian Jabandziev, Petr Leboráns Iglesias, Pilar Lau, Yu Lung Zhang, Shen Ying Ling, Yun Viz Lasheras, Sandra Lucas, Carrie L. Mansouri, Davood Maródi, László Guerra Liñares, Beatriz Ostrowski, Sisse Rye Trouillet Assant, Sophie Puel, Anne Elmas Bozdemir, Sefika Keles, Sevgi Rodríguez Núñez, Nuria Cooper, Megan A. Novelli, Antonio Prando, Carolina Valdés Cuadrado, Luis Haerynck, Filomeen Pujol, Aurora Brodin, Petter Al Mulla, Fahd Puel, Anne Quintana Murci, Lluis López Lago, Ana Husebye, Eystein Ramaswamy, Sathishkumar Vilas Iglesias, María Soledad Renia, Laurent Cobat, Aurélie Lendoiro Fuentes, Marta Colobran, Roger Resnick, Igor Rodríguez Gallego, Carlos Pan Hammarström, Qiang Varela García, Pablo Dacosta Urbieta, Ana Isabel Pape, Jean W. Sancho Shimizu, Vanessa Abi Haidar, Anthony Pardo Seco, Jacobo Trouillet Assant, Sophie Abel, Laurent Sediva, Anna Tandjaoui Lambiotte, Yacine Seppänen, Mikko R.J. Froidure, Antoine Shahrooei, Mohammed Shcherbina, Anna Rodríguez Tenreiro Sánchez, Carmen Slaby, Ondrej Snow, Andrew L. Díaz Esteban, Blanca Jouanguy, Emmanuelle Prando, Carolina Hatipoglu, Nevin López Franco, Montserrat Vinh, Donald C. Cobat, Aurélie Pan-hammarström, Qiang Tiberghien, Pierre Duval, Xavier Boisson, Bertrand Fellay, Jacques Bastón Rey, Iria Salas, Antonio Béziat, Vivien Condino Neto, Antonio Hsieh, Elena W.y. Borghesi, Alessandro Pession, Andrea Covid Clinicians Itan, Yuval Saborido Paz, Eva Andreakos, Evangelos Bousfiha, Ahmed A. Franco, José Luis Marr, Nico Bayhan, Gülsün Iclal Mentis, Alexios Fotios A. Okada, Satoshi Hammarström, Lennart Mogensen, Trine H. Rodríguez Gallego, Carlos Flores, Carlos Sadiki Orayyou, José Miguel Fernández Villaverde, Juan Ferreiro Iglesias, Rocio Núñez Masid, Eloína Mentré, France Tancevski, Ivan Ahlijah, Gloria Gen Covid Study Group Novelli, Giuseppe Zatz, Mayana Covid Human Genetic Effort Perlin, David S. Soudee, Camille Arseguel, Vincent Grimbacher, Bodo Lévy, Romain Abolhassani, Hassan Ozcelik, Tayfun Sahanic, Sabina Galbán Rodríguez, Cristóbal Gorochov, Guy Tancevski, Ivan Nukui, Yoko Tüter Öz, Şadiye Kübra O’farrelly, Cliona Condino Neto, Antonio Okada, Satoshi Hayakawa, Seiichi García Vicente, Luisa Heath, James R. Aguilera Albesa, Sergio Chrousos, George P. Ortolá Devesa, Juan Bautista Michos, Athanasios Beek, Diederik Van De Tatsi, Elizabeth Barbara Filippatos, Filippos Duvlis, Sotirija Rodriguez Palmero, Agusti Troya, Jesus Constantinescu, Stefan N. Serén Fernández, Sonia Aiuti, Alessandro Gregersen, Peter K. Marseglia, Gian Luigi Soler Palacín, Pere Kisand, Kai El Bakkouri, Jalila Temel, Şehime Gülsün Metin Akcan, Ozge Turvey, Stuart E. Javouhey, Etienne Kılıç, Ahmet Osman Souto Sanmartín, Pablo Pujol, Aurora Ozkaya Parlakay, Aslinur Papadaki, Maria Giráldez Vázquez, Elena Quartier, Pierre Meyts, Isabelle Slaba, Katerina Uddin, Mohammed J. Sevketoglu, Esra Al Muhsen, Saleh Valencia Ramos, Juan Salas, Antonio Yahşi, Aysun Aguilera Guirao, Antonio Pérez Freixo, Hugo Furkan Uddin, K.M. Milner, Joshua D. Okamoto, Keisuke |
Keywords: | Autoanticossos COVID-19 Autoantibodies COVID-19 |
Issue Date: | 4-Jan-2024 |
Publisher: | Rockefeller University Press |
Abstract: | We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2. |
Note: | Reproducció del document publicat a: https://doi.org/10.1084/jem.20231353 |
It is part of: | Journal of Experimental Medicine, 2024, vol. 221, num. 2 |
URI: | http://hdl.handle.net/2445/207702 |
Related resource: | https://doi.org/10.1084/jem.20231353 |
ISSN: | 1540-9538 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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