Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/207993
Title: Effect of Fish Oil Parenteral Emulsion Supplementation on Inflammatory Parameters after Esophagectomy
Author: Suárez Lledó, Ana
Llop Talaveron, Josep M.
Leiva Badosa, Elisabet
Farran Teixido, Leandre
Miró Martín, Mónica
Bas Minguet, Jordi
Navarro Velázquez, Sergio
Creus Costas, Gloria
Virgili Casas, Nuria
Fernández Álvarez, Mónica
Badía Tahull, María B.
Keywords: Suplements nutritius
Emulsions
Dietary supplements
Emulsions
Issue Date: 21-Dec-2023
Publisher: MDPI AG
Abstract: (Background) Esophagectomy (EPG) presents high morbidity and mortality. Omega-3 fatty acids (omega-3FA) are a pharmaconutrient with benefits for postoperative morbidity. Studies of omega-3FA administered parenterally after esophagectomy are scarce. This study proposes to investigate the effect of combining fish oil lipid emulsions (LE) administered parenterally with enteral nutrition support. (Methods) Randomization was 1:1:1 in three groups: Group A received a LE mixture of 0.4 g/kg/day of fish oil and 0.4 g/kg/day of LCT/MCT 50:50, Group B received 0.8 g/kg/day of fish oil LE, and Group C received 0.8 g/kg/day of LCT/MCT 50:50. Variables were measured at recruitment time and day +1, +3, and +5. Inflammatory variables studied were Interlukin-6, C-reactive protein (CRP), tumoral necrosis factor-alpha (TNF-alpha), IL-10, IL-8 and CD25s. Safety, nutritional parameters and complications were analyzed. (Results) Administration of omega-3LE in the immediate postoperative period did not modulate the earlier inflammatory response. Statistically significant differences were found in IL-6 and CRP overall temporal evolution but were not found when studying the type of LE administered or in patients needing critical care. Administration of omega-3 resulted in safe and improved hypertriglyceridemia, depending on the dose. (Conclusions) omega-3FA has no impact on the early inflammatory postoperative response assessed for a short period but was safe. More studies for longer periods are needed.
Note: Reproducció del document publicat a: https://doi.org/10.3390/nu16010040
It is part of: Nutrients, 2023, vol. 16, num. 1, p. 40
URI: http://hdl.handle.net/2445/207993
Related resource: https://doi.org/10.3390/nu16010040
ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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