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Title: | Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year |
Author: | Domínguez López, Inés Arancibia Riveros, Camila Casas Rodríguez, Rosa M. Tresserra i Rimbau, Anna Razquin, Cristina Martínez-González, Miguel Ángel, 1957- Hu, Frank B. Ros Rahola, Emilio Fitó Colomer, Montserrat Estruch Riba, Ramon López Sabater, María del Carmen Lamuela Raventós, Rosa Ma. |
Keywords: | Plasma sanguini Cuina mediterrània Àcids grassos saturats Inflamació Malalties cardiovasculars Diabetis Blood plasma Mediterranean cooking Saturated fatty acids Inflammation Cardiovascular diseases Diabetes |
Issue Date: | Jun-2022 |
Publisher: | Elsevier Masson SAS |
Abstract: | Systemic inflammation is associated with an increased risk of non-communicable diseases, such as cardiovascular diseases and diabetes. Circulating fatty acids (FA) are known to be related to these conditions, possibly through their role in inflammation, although different types of FAs can have opposite effects on inflammatory mediators. The aim of the present study was to analyze the association of plasma FAs with inflammatory biomarkers in a PREDIMED trial subsample after one year of intervention. In a one-year longitudinal study of 91 participants of the PREDIMED trial (Barcelona-Clinic center), plasma FAs and inflammatory biomarkers were analyzed using gas chromatography and ELISA, respectively. In baseline plasma, a multivariable-adjusted ordinary least squares regression model showed that n-3 polyunsaturated FAs concentrations were inversely associated with concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) and E-selectin, whereas the level of the most abundant saturated FA, palmitic acid, was directly associated with concentrations of interleukin-6 (IL-6) (β = 0.48 pg/mL, 95% CI: 0.03, 0.93 per 1-SD increase, p-value = 0.037). After one year of nutritional intervention, changes of plasma diet-derived total saturated FAs and palmitic acid were directly associated with changes in IL-6 (β = 0.59 pg/mL [95% CI: 0.28, 0.89] per 1-SD, p-value = 0.001; β = 0.64 pg/mL, 95% CI: 0.31, 0.98, p-value = 0.001), respectively, after correction for multiple testing. Our findings suggest that saturated FAs of dietary origin, especially palmitic acid, are directly involved in the increase of IL-6 in plasma. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.biopha |
It is part of: | Biomedicine & Pharmacotherapy, 2022, vol. 150 |
URI: | http://hdl.handle.net/2445/208782 |
Related resource: | https://doi.org/10.1016/j.biopha |
ISSN: | 0753-3322 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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